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ASC / TMS1 Polyclonal Antibody

ASC / TMS1 Polyclonal Antibody

Item no.	E-AB-60228-200
Manufacturer	Elabscience
Amount	200 uL
Quantity options	120 uL 200 uL 60 uL
Category	Antibodies Western Blot Immunofluorescence Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies
Type	Antibody Polyclonal
Applications	WB, IF
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	https://www.sciencedirect.com/science/article/pii/S1567576923002242 https://www.nature.com/articles/s41598-022-04785-z https://journals.lww.com/neuroreport/Fulltext/2021/06020/Protective_effects_of_melatonin_on_the_white.1.aspx?context=LatestArticles
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	PYCARD, ASC, CARD5, TMS, TMS-1, TMS1, PYD and CARD domain containing, ASC / TMS1
Similar products	ASC, TMS1, TMS, PYCARD, CARD5, Apoptosis-associated speck-like protein containing a CARD, Caspase recruitment domain-containing protein 5, PYD and CARD domain-containing protein, Target of methylation-induced silencing 1, MGC10332, TMS 1, Apoptosis associated speck like protein containing a CARD, CARD 5, Caspase recruitment domain containing protein 5, Caspase recruitment domain protein 5, hASC, PYD and CARD domain containing, PYD and CARD domain containing protein, Target of methylation induced silencing 1
Shipping Condition	Cool pack
Hazard information	Comply with cargo safety certificate
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	ASC / TMS1
Shipping Temperature	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight	15kDa/19kDa/21kDa
Observed Molecular Weight	22kDa
Manufacturer - Research Areas	Cancer, Cell Biology
Background	This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
Concentration	1mg/mL
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method	Affinity purification
Recommended Dilution	WB 1:500-1:2000; IF 1:50-1:200
Abbreviation	ASC / TMS1
Clonality	Polyclonal
Immunogen	Recombinant fusion protein of human ASC / TMS1 (NP_037390.2).
Category ID III	Polyclonal Antibodies

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.