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SHC1 Polyclonal Antibody

SHC1 Polyclonal Antibody

Item no.	E-AB-62212-60
Manufacturer	Elabscience
Amount	60 uL
Quantity options	120 uL 200 uL 60 uL
Category	Neuroscience Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	IF, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	SHC, SHCA, SHC1
Similar products	SHC1, Shc, SHC-transforming protein 1, SHC-transforming protein A, Src homology 2 domain-containing-transforming protein C1, FLJ26504, SHCA, p66, SHC-transforming protein 3, SH2 domain protein C1, p66SHC, SHC 1, SHC A, SHC transforming protein 1, SHC transforming protein, SHC (Src homology 2 domain containing) transforming protein 1, SHC adaptor protein 1
Shipping Condition	Cool pack
Hazard information	Comply with cargo safety certificate
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	SHC1
Shipping Temperature	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight	40kDa/46kDa/51kDa/62kDa
Observed Molecular Weight	46kDa/52kDa/66kDa
Research Areas	Cancer, Neuroscience, Signal Transduction
Background	This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
Concentration	1mg/mL
Buffer	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method	Affinity purification
Recommended Dilution	IHC 1:50-1:200; IF 1:50-1:200
Abbreviation	SHC1
Clonality	Polyclonal
Immunogen	A synthetic peptide of human SHC1
Category ID III	Polyclonal Antibodies

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.