IRF4 Polyclonal Antibody

Store at -20C. Avoid freeze / thaw cycles.

52kDa

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6; 14)(p25; q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.

PBS with 0.02% sodium azide and 50% glycerol pH 7.4

WB1:500 - 1:2000