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Phospho-AMPK alpha1/2 (Thr183/172) Polyclonal Antibody

Phospho-AMPK alpha1/2 (Thr183/172) Polyclonal Antibody

Item no.	E-AB-21121-60
Manufacturer	Elabscience
Amount	60 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Category	Oncology Metabolism Cholesterol & Lipid Metabolism Antibodies By Cell Type Hematology Lymphoma Cell Biology Obesity Cell Status Immunohistochemistry Western Blot ELISA Immunofluorescence Autophagy Cardiovascular Research Enzymes Hypertension Fatty Acid Synthesis Primary Antibodies
Type	Antibody Polyclonal
Applications	WB, IF, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Monkey (Cynomolgus, Simian)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	https://www.mdpi.com/1960060 https://www.mdpi.com/1907994
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	PRKAA1, AMPK1, 5'-AMP-activated protein kinase catalytic subunit alpha-1, AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, Tau-protein kinase PRKAA1, PRKAA2, AMPK,
Similar products	PRKAA1, PRKAA2, AMPK1, 5'-AMP-activated protein kinase catalytic subunit alpha-1, Acetyl-CoA carboxylase kinase, Hydroxymethylglutaryl-CoA reductase kinase, Tau-protein kinase PRKAA1, AMPK, AMPK subunit alpha-1, ACACA kinase, HMGCR kinase
Shipping Condition	Cool pack
Hazard information	Comply with cargo safety certificate
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	AMPKα1/2 (phospho Thr183/172)
Shipping Temperature	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight	62kDa
Observed Molecular Weight	63kDa
Manufacturer - Research Areas	Cancer, Cardiovascular, Metabolism, Neuroscience, Signal Transduction
Background	AMPK (for 5'-AMP-activated protein kinase) is a heterotrimeric complex comprising a catalytic α subunit and regulatory β and γ subunits. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is activated by high AMP and low ATP through a mechanism involving allosteric regulation, promotion of phosphorylation by an upstream protein kinase known as AMPK kinase, and inhibition of dephosphorylation.Activated AMPK can phosphorylate and regulate in vivo hydroxymethylglutaryl-CoA reductase and acetyl-CoA carboxylase, which are key regulatory enzymes of sterol synthesis and fatty acid synthesis, respectively.
Concentration	1 mg/mL
Buffer	PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Purification Method	Affinity purification
Recommended Dilution	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:50-1:200
Abbreviation	AMPKα1/2 (phospho Thr183/172)
Clonality	Polyclonal
Immunogen	Synthesized peptide derived from human AMPKα1/2 around the phosphorylation site of Thr183/172
Category ID III	Acetyl/Phospho/Methyl Antibodies

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.