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Phospho-p70 S6 kinase alpha (Ser447) Polyclonal Antibody

Phospho-p70 S6 kinase alpha (Ser447) Polyclonal Antibody

Item no.	E-AB-20959-20
Manufacturer	Elabscience
Amount	20 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Category	Oncology Neuroscience Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Immunohistochemistry Western Blot ELISA Primary Antibodies Astrocytoma
Type	Antibody Polyclonal
Applications	WB, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	70 kDa ribosomal protein S6 kinase 1, KS6B1, p70 alpha, P70 beta 1, p70 ribosomal S6 kinase alpha, p70 ribosomal S6 kinase beta 1, p70 S6 kinase alpha, P70 S6 Kinase, p70 S6 kinase, alpha 1, p70 S6 kinase, alpha 2, p70 S6K, p70 S6K-alpha, p70 S6KA, p70(S6K) alpha, p70(S6K)-alpha, p70-alpha, p70-S6K 1, p70-S6K, P70S6K, P70S6K1, p70S6Kb, PS6K, Ribosomal protein S6 kinase 70kDa polypeptide 1, Ribosomal protein S6 kinase beta 1, Ribosomal protein S6 kinase beta-1, Ribosomal protein S6 kinase I, RPS6KB1, S6K, S6K-beta-1, S6K1, Serine/threonine kinase 14 alpha, Serine/threonine-protein kinase 14A, STK14A
Similar products	p70-S6K, RPS6KB1, p70S6Kb, Ribosomal protein S6 kinase beta-1, 70 kDa ribosomal protein S6 kinase 1, Ribosomal protein S6 kinase I, p70 ribosomal S6 kinase alpha, STK14A, Serine/threonine-protein kinase 14A, p70 S6 kinase alpha, alpha 1, alpha 2, PS6K, S6K, S6K1, p70(S6K)-alpha, p70-alpha, p70 S6 kinase, KS6B1, S6K-beta-1, P70S6K1, p70-S6K 1, p70 S6K-alpha, p70 S6KA, p70 alpha, P70 beta 1, p70 ribosomal S6 kinase beta 1, P70 S6 Kinase, p70 S6K, P70S6K, Ribosomal protein S6 kinase 70kDa polypeptide 1, Ribosomal protein S6 kinase beta 1, Serine/threonine kinase 14 alpha
Shipping Condition	Cool pack
Hazard information	Comply with cargo safety certificate
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	p70 S6 kinase α (phospho Ser447)
Shipping Temperature	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight	59kDa
Observed Molecular Weight	60kDa
Manufacturer - Research Areas	Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction
Background	P70 S6 Kinase alpha is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases and contains 2 non-identical kinase catalytic domains. It phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein is activated by serine/threonine phosphorylation and protein kinase C and inactivated by type 2A phosphatase. Activation leads to an increase in protein synthesis and cell proliferation. Overexpression of this kinase is involved in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
Concentration	1 mg/mL
Buffer	PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Purification Method	Affinity purification
Recommended Dilution	WB 1:500-1:2000; IHC 1:100-1:300
Abbreviation	p70 S6 kinase α (phospho Ser447)
Clonality	Polyclonal
Immunogen	Synthesized peptide derived from human p70 S6 kinase α around the phosphorylation site of Ser447
Category ID III	Acetyl/Phospho/Methyl Antibodies

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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