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BCL-x Polyclonal Antibody

BCL-x Polyclonal Antibody

Item no.	E-AB-30640-60
Manufacturer	Elabscience
Amount	60 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Category	Oncology Antibodies By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot ELISA Immunofluorescence Autophagy Cardiovascular Research Ischemia & Reperfusion Injury Primary Antibodies By Organ Skin Cancer Colorectal Cancer Testicular & Prostate Cancer
Type	Antibody Polyclonal
Applications	WB, IF, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Apoptosis regulator Bcl X, Apoptosis regulator Bcl-X, Apoptosis regulator BclX, B cell lymphoma 2 like, B2CL1, Bcl 2 like 1 protein, Bcl X, Bcl xL, BCL XL/S, Bcl xS, Bcl-2-like protein 1, Bcl2 Like 1, Bcl2 related gene, Bcl2-L-1, BCL2L, Bcl2l1, BCLX, BclXL, BclXs, DKFZp781P2092, PPP1R52, Protein phosphatase 1 regulatory subunit 52
Similar products	Bcl-2-like protein 1, Bcl2-L-1, Apoptosis regulator Bcl-X, BCLX, BCL2L, DKFZp781P2092, B2CL1, BclXL, PPP1R52, Apoptosis regulator Bcl X, Bcl 2 like 1 protein, Bcl xL, BCL XL/S, Bcl xS, Apoptosis regulator BclX, B cell lymphoma 2 like, Bcl X, Bcl2 Like 1, Bcl2 related gene, Bcl2l1, BclXs, Protein phosphatase 1 regulatory subunit 52
Shipping Condition	Cool pack
Hazard information	Comply with cargo safety certificate
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	Bcl-x
Shipping Temperature	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight	26kDa
Observed Molecular Weight	30kDa
Manufacturer - Research Areas	Cancer, Cell Biology, Metabolism, Signal Transduction
Background	Bcl x is a member of the Bcl 2 family of proteins, which function as regulators of apoptosis. It may provide neuroprotection against ischemic brian injury. Bcl x has two isoforms, Bcl xl (long) a 241 amino acid protein and Bcl xs (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the Bcl2 family. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.
Concentration	1 mg/mL
Buffer	PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Purification Method	Affinity purification
Recommended Dilution	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000
Santa Cruz #	sc-7122, sc-8275, sc-8276, sc-8277, sc-8278, sc-7195, sc-1041, sc-634, sc-1690
Abbreviation	Bcl-x
Clonality	Polyclonal
Immunogen	Synthesized peptide derived from human Bcl-x around the non-phosphorylation site of Thr47.
Category ID III	Polyclonal Antibodies

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.