GSK3 alpha/beta Polyclonal Antibody

GSK3α/β

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

51, 46kDa

Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3 kinase/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3βGSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization.

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

WB 1:500-1:2000; IHC 1:100-1:300

Polyclonal

Polyclonal Antibodies