TSLP[Biotinylated]:IL-7Rα & TSLP R Inhibitor Screening ELISA Kit

IL-7 R alpha & TSLP R

Thymic stromal lymphopoietin (TSLP) exerts its biological effects by binding to a high-affinity heteromeric complex composed of thymic stromal lymphopoietin receptor chain and IL-7Rα.The formation of the ternary complex, TSLPR:TSLP: IL-7Rα, initiates signaling in cells co-expressing TSLPR and IL-7Rα.TSLP has been implicated in a variety of allergic diseases (e.g., atopic dermatitis, bronchial asthma, eosinophilic esophagitis). Therefore, inhibition of TSLP interaction with TSLP receptor complex has been considered a promising strategy to blocks thymic stromal lymphopoietin (TSLP) function and prevents the overreactive immune response to allergic, eosinophilic and other types of airway inflammation associated with severe asthma.

This kit is developed for screening for inhibitors of human PD-1 binding to human IL-7Rα & TSLP R.