IL17C Chemi-Luminescent ELISA Kit (Mouse)

ELISA Kit

Wet Ice

interleukin 17C

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NFKB and MAPK pathways. Acts synergically with IL22, TNF and IL1B in inducing antibacterial peptides. May have protective function by maintaining epithelial homeostasis after an inflammatory challenge, such as that caused in the intestine by dextran sulfate sodium in a colitis model. May also promote an inflammatory phenotype, such as skin in a psoriasis model. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases, such as autoimmune encephalitis.

NP_665833

Assay Methodology: Quantitative Sandwich ELISA

Chemiluminescent

Sample - 1:2 - 1:4 - 1:8 - 1:16
Serum (n=5) - 85-95% - 87-101% - 85-92% - 80-105%
EDTA Plasma (n=5) - 95-104% - 88-96% - 83-94% - 79-92%
Heparin Plasma (n=5) - 98-105% - 88-97% - 90-101% - 81-103%

Matrix - Recovery range (%) - Average(%)
Serum (n=5) - 89-99 - 93
EDTA Plasma (n=5) - 98-105 - 102
Heparin Plasma (n=5) - 87-95 - 91

Serum, plasma and other biological fluids