IL-1alpha ELISA Kit, Mouse

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of mouse IL-1alpha . The Mouse IL-1alpha ELISA is for research use only. Not for diagnostic or therapeutic procedures. Interleukin-1 (IL-1) is an extracellular peptide of 17 kDa that designates two proteins, IL-1alpha and IL-1beta. IL-1alpha is a pleiotropic cytokine that in humans is encoded by the IL1A gene. IL-1alpha is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. IL-1alpha has been shown to interact with HAX1 and NDN, but the most clinically relevant is its synergism with TNF. IL-1alpha and TNF are both acute-phase cytokines that act to promote fever and inflammation. IL-1alpha is currently being evaluated in clinical trials as a potential therapeutic in oncology indications. Blocking the activity of IL-1alpha has the potential to treat skin diseases such as acne.

Sandwich ELISA

serum, plasma, cell culture supernates

4C (unopened)
standard stored at -20C, others stored at 4C (opened)

1.68 pg/ml

71 % - 106 %

n.d. - 49.5 pg/ml

4.7 % - 7.7 %