PIK3C3 ELISA Kit (Human) (OKCD00715)

phosphatidylinositol 3-kinase catalytic subunit type 3

5289

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).By similarity < p>Manually curated information which has been propagated from a related experimentally characterized protein.< /p> < p>< a href="/manual/evidences#ECO:0000250">Moreâa‚¬A< /a>< /p> Manual assertion inferred from sequence similarity toiUniProtKB:O88763  (PK3C3_RAT)Curated4 Publications < p>Manually curated information for which there is published experimental evidence.< /p> < p>< a href="/manual/evidences#ECO:0000269">Moreâa‚¬A< /a>< /p> Manual assertion based on experiment iniRef.1"A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system."_x005F_x000D_ Volinia S., Dhand R., Vanhaesebroeck B., MacDougall L.K., Zvelebil M.J., Domin J., Panaretou C., Waterfield M.D._x005F_x000D_ EMBO J. 14:3339-3348(1995) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, COFACTOR, SUBUNIT, TISSUE SPECIFICITY, INTERACTION WITH PIK3R4.Ref.3"Human VPS34 and p150 are Rab7 interacting partners."_x005F_x000D_ Stein M.P., Feng Y., Cooper K.L., Welford A.M., Wandinger-Ness A._x005F_x000D_ Traffic 4:754-771(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH RAB7A AND PIK3R4, SUBCELLULAR LOCATION.Ref.7"A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic."_x005F_x000D_ Thoresen S.B., Pedersen N.M., Liestol K., Stenmark H._x005F_x000D_ Exp. Cell Res. 316:3368-3378(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT.Ref.9"PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody."_x005F_x000D_ Sagona A.P., Nezis I.P., Pedersen N.M., Liestol K., Poulton J., Rusten T.E., Skotheim R.I., Raiborg C., Stenmark H._x005F_x000D_ Nat. Cell Biol. 12:362-371(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION.

< 0.59 ng/mL