IL6ST ELISA Kit (Human) (OKCD00784)

Wet Ice

918

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).By similarity < p>Manually curated information which has been propagated from a related experimentally characterized protein.< /p> < p>< a href="/manual/evidences#ECO:0000250">Moreâa‚¬A< /a>< /p> Manual assertion inferred from sequence similarity toiUniProtKB:Q00560  (IL6RB_MOUSE)3 Publications < p>Manually curated information for which there is published experimental evidence.< /p> < p>< a href="/manual/evidences#ECO:0000269">Moreâa‚¬A< /a>< /p> Manual assertion based on experiment iniRef.1"Molecular cloning and expression of an IL-6 signal transducer, gp130."_x005F_x000D_ Hibi M., Murakami M., Saito M., Hirano T., Taga T., Kishimoto T._x005F_x000D_ Cell 63:1149-1157(1990) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT VAL-8.Ref.18"N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130."_x005F_x000D_ Waetzig G.H., Chalaris A., Rosenstiel P., Suthaus J., Holland C., Karl N., Valles Uriarte L., Till A., Scheller J., Grotzinger J., Schreiber S., Rose-John S., Seegert D._x005F_x000D_ J. Biol. Chem. 285:1781-1789(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION.Ref.20"gp130 activation is regulated by D2-D3 interdomain connectivity."_x005F_x000D_ Schutt A., Zacharias M., Schneider N., Horn S., Grotzinger J., Rose-John S., Schmidt-Arras D._x005F_x000D_ Biochem. J. 450:487-496(2013) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, MUTAGENESIS OF CYS-172; 186-TYR--TYR-190; VAL-189; TYR-190; ASP-215 AND VAL-252.

Assay Methodology: Quantitative Sandwich Immunoassay