ADRA1A ELISA Kit (Human) (OKCD00827)

Alpha-1A adrenergic receptor

148

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.2 Publications < p>Manually curated information for which there is published experimental evidence.< /p> < p>< a href="/manual/evidences#ECO:0000269">Moreâa‚¬A< /a>< /p> Manual assertion based on experiment iniRef.16"Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes."_x005F_x000D_ Wright C.D., Chen Q., Baye N.L., Huang Y., Healy C.L., Kasinathan S., O'Connell T.D._x005F_x000D_ Circ. Res. 103:992-1000(2008) [PubMed] [Europe PMC] [Abstract]Cited for: SUBCELLULAR LOCATION, FUNCTION.Ref.17"Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes."_x005F_x000D_ Wright C.D., Wu S.C., Dahl E.F., Sazama A.J., O'Connell T.D._x005F_x000D_ Cell. Signal. 24:794-802(2012) [PubMed] [Europe PMC] [Abstract]Cited for: SUBCELLULAR LOCATION, SUBUNIT, FUNCTION, MUTAGENESIS OF LYS-334; LYS-335; ARG-342; ARG-348 AND LYS-349.

< 0.119 ng/mL