CASP1 Antibody

This antibody is also available with the following conjugates:
AF350, AF405L, AF405M, AF405S, AF488, AF514, AF532, AF546, AF555, AF568, AF594, AF610, AF635, AF647, AF680, AF700, AF750, AF790, APC, AP, Biotin, Cy3, Cy5.5, Cy5, Cy7, FITC, HRP, PE, Magnetic beads (1 um, 2.8 um, 3 um, 4.5 um, 5 um, 10 um, 15 um, 20 um, 30 um, or different size option)
Please contact sales@hoelzel.de for pricing and availability.

45kDa

Affinity purification

Caspase-1, or interleukin-1ß converting enzyme (ICE/ICEalpha), is a class I cysteine protease, which also includes caspases -4, -5, -11, and -12. Caspase-1 cleaves inflammatory cytokines such as pro-IL-1ß and interferon-gamma inducing factor (IL-18) into their mature forms (1, 2). Like other caspases, caspase-1 is proteolytically activated from a proenzyme to produce a tetramer of its two active subunits, p20 and p10. Caspase-1 has a large amino-terminal pro-domain that contains a caspase recruitment domain (CARD). Overexpression of caspase-1 can induce apoptosis (3). Mice deficient in caspase-1, however, have no overt defects in apoptosis but do have defects in the maturation of pro-IL-1beta and are resistant to endotoxic shock (4, 5). At least six caspase-1 isoforms have been identified, including caspase-1 alpha, beta, gamma, delta, epsilon and zeta (6). Most caspase-1 isoforms (alpha, beta, gamma and delta) produce products between 30-48 kDa and induce apoptosis upon over-expression. Caspase-1 epsilon typically contains only the p10 subunit, does not induce apoptosis and may act as a dominant negative. The widely expressed zeta isoform of caspase-1 induces apoptosis and lacks 39 amino-terminal residues found in the alpha isoform (6). Activation of caspase-1 occurs through an oligomerization molecular platform designated the "inflammasome" that includes caspase-5, Pycard/Asc, and NALP1 (7).