APP Antibody

WB 1:500-1:2000
IHC 1:50-1:200
IF:1:10-1:100

Store at -20C/1 year

N term -peptideof human APP

Amyloid beta (Abeta) precursor protein (APP) is a 100-140 kDatransmembrane glycoprotein that exists as several isoforms (1). The amino acid sequence of APP contains the amyloid domain (Abeta), which can be released by a two-step proteolytic cleavage (1). The extracellular deposition and accumulation of the released Abeta fragments form the main components of amyloid plaques in Alzheimer's disease (1). APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein (2-5). Phosphorylation at Thr668 (at a position corresponding to the APP695 isoform) by cyclin-dependent kinase is cell cycle-dependent and peaks during G2/M-phase (4). APP phosphorylated at Thr668 exists in adult rat brain and correlates with cultured neuronal differentiation (5, 6).

EN0042736