Manufacturer |
Enogene
|
Category |
|
Type |
Antibody |
Specific against |
Human, Mouse, Rat |
Applications |
Immunofluorescence, Western Blot |
Amount |
100ul |
Host |
Rabbit |
Item no. |
E90095 |
Targets |
NGF ;; SHH |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Alias |
SHH, HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS |
Background |
Hedgehog proteins (Hh) are secreted signaling proteins that play many roles during animal development. Aberrant Hh signaling activity can be associated with numerous birth defects and uncontrolled Hh pathway activation is linked to the development of several types of cancers (1-2). The three identified vertebrate Hh genes are Sonic (Shh), Indian (Ihh) and Desert (Dhh), all of which have distinct as well as overlapping roles (3-5). Hh proteins are synthesized as 45 kDa precursors that undergo auto-cleavage to generate a 19 kDa amino-terminal peptide (Hh-N) and a carboxy-terminal peptide (Hh-C). The amino-terminal peptide becomes covalently attached to a cholesterol molecule at its carboxy terminus and acetylated at its amino terminus. This doubly modified Hh-N peptide is released from cells and responsible for all known Hedgehog signaling activity (6). |
Research Area |
Autophagy antibody, Cancer, Cardiovascular, Cell Biology, Epigenetics and Nuclear Signaling, Developmental Biologys, Immunology, Drug Discovery Products, Metabolism, Neuroscience, Signal Transduction, Stem Cells |
Swiss-Prot No. |
Q15465 |
Altername |
SHH, HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS |
Immunogen |
A synthetic peptideof human SHH |
Purification |
Affinity purification |
Applications information |
WB IF |
Gene ID |
6469 |
Molecular Weight |
50kDa |
Storage/Stability |
Store at -20C or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.