Manufacturer |
Enogene
|
Category |
|
Type |
Antibody |
Specific against |
Human, Mouse, Rat |
Applications |
Western Blot, Immunohistochemistry |
Amount |
100ul |
Host |
Rabbit |
Item no. |
E92550 |
Targets |
TNFSF11 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Background |
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. |
Research Area |
Autophagy antibody, Cancer, Cardiovascular, Cell Biology, Epigenetics and Nuclear Signaling, Developmental Biologys, Immunology, Drug Discovery Products, Metabolism, Neuroscience, Signal Transduction, Stem Cells |
Swiss-Prot No. |
O14788 |
Altername |
ODF, OPGL, sOdf, CD254, OPTB2, RANKL, TRANCE, hRANKL2, |
Immunogen |
Recombinant protein of human TNFSF11 |
Purification |
Affinity purification |
Applications information |
WB IHC |
Gene ID |
8600 WB 1:500 - 1:2000 IHC 1:50-1:200 |
Molecular Weight |
35kDa |
Storage/Stability |
Store at -20C or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
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