IL-4

The Product is shipped at ambient temperature. Upon reconstitution, the preparation is stable for up to 1 month at 2-8C. For long term storage, apportion the reconstituted preparation into working aliquots and store at -20C to -70C. Avoid repeated freeze/thaw cycles.

IL-4 (interleukin 4) is a pleiotropic type I cytokine implicated in the development of Th2-mediated responses, which is associated with allergy and asthma. IL-4 is secreted by activated Th2, natural killer T cells and mast cells. IL-4 induces differentiation of naive T cells into the TH2 phenotype. IL-4 also promotes B cell proliferation, antibody isotype switching and expression of other TH2 cytokines including IL-5 and IL-9. There are two types of IL-4 receptors, the type I receptor is a heterodimer consisting of IL-4Ralpha chain and the common gamma chain(gammac), which is also shared by the cytokines IL-2, -7, -9, -15 and -21; and the type II receptor is a heterodimer of IL-4Ralpha and IL-13Ralpha1, which is shared with IL-13.