IL-6

The Product is shipped at ambient temperature. Upon reconstitution, the preparation is stable for up to 1 month at 2-8C. For long term storage, apportion the reconstituted preparation into working aliquots and store at -20C to -70C. Avoid repeated freeze/thaw cycles.

IL-6 (interleukin 6) or B-cell stimulatory factor 2, is a pleotropic, pro-inflammatory cytokine that stimulates hepatocytes to produce acute phase proteins, and induces growth and differentiation of B cells, T cells, and hepatocytes. IL-6 is predominately produced by T cells, macrophages, fibroblasts, endothelial cells and keratinocytes. IL-6 is considered as a potential marker of adipocyte differentiation. IL-6 binds to IL-6Ralpha that through association induces gp130 homodimerization which triggers the Jak/STAT cascade and the SHP2/Erk Map kinase cascade.