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Biotinylated Cynomolgus Fc gamma RIIB / CD32b Protein, His,Avitag™ (SPR & BLI & MALS verified)

Biotinylated Cynomolgus Fc gamma RIIB / CD32b Protein, His,Avitag™ (SPR & BLI & MALS verified)

Item no.	CDB-C82E4-200ug
Manufacturer	ACROBiosystems
Amount	200 ug
Quantity options	200 ug 25 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Solid
Specific against	Monkey (Cynomolgus, Simian)
Host	HEK293
Conjugate/Tag	Biotin, Avi
Purity	95%
Citations	(1) Hamada F., et al., 1993, Proc. Natl. Acad. Sci. U.S.A. 90:6305-6309. (2) Sarmay G., et al., 1997, Immunol. Lett. 57:159-164. (3) Laine D., et al., 2005, J. Gen. Virol. 86:1771-1784.
NCBI	NP_001271060.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	FCGR2B,CD32b,CD32,FCG2,IGFR2,CDw32
Shipping Condition	Room temperature
Available
Specificity	Cynomolgus
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	C-10xHis & C-Avi, Biotin-labeled
Shipping Temperature	RT
Storage Conditions	-20°C
Molecular Weight	23.6 kDa
Manufacturer - Format	Powder
Description	Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.
Background	Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B) is also known as CD32b, FCG2, IGFR2. CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.
Molecule	Fc gamma RIIB / CD32b
Exp Region	Ala 46 - Pro 224
Characteristics	This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 23.6 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● -20°C to -70°C for 12 months in lyophilized state ● -70°C for 12 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant	trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

CDB-C82E4-200ug-datasheet.pdf

CDB-C82E4-200ug-safety-datasheet.pdf