Comparison

Biotinylated Cynomolgus / Rhesus macaque FcRn Heterodimer Protein, His,Avitag™&Streptavidin II Tag (HPLC&SPR&BLI verified) European Partner

Item no. FCM-C82W5-25ug
Manufacturer ACROBiosystems
Amount 25 ug
Quantity options 200 ug 25 ug
Category
Type Proteins Recombinant
Format Solid
Specific against Monkey (Cynomolgus, Simian), Rhesus macaque
Host HEK293
Conjugate/Tag Streptavidin II, Biotin, Avi
Purity 90%
Citations (1) Goebl NA., et al., 2008, Mol. Biol. Cell 19 (12): 5490-505. (2) Lee TY., et al., 2008, Clin. Cancer Res. 14 (5): 1487-93. (3) Güssow D., et al., 1987, J. Immunol. 139 (9): 3132-8. (4) Gorevic P.D., et al., 1986, Proc. Natl. Acad. Sci. U.S.A. 83:7908-7912.
NCBI NP_001244449.1 (FCGRT), Q8SPW0.1 (B2M)
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias FcRn,FCGRT & B2M
Shipping Condition Room temperature
Available
Specificity Cynomolgus / Rhesus macaque
Manufacturer - Category
Protein
Manufacturer - Conjugate / Tag
C-10xHis & C-Avi | C-Streptavidin II, Biotin-labeled
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
34.1 kDa (FCGRT) & 13.0 kDa (B2M)
Manufacturer - Format
Powder
Description
MABSol® Biotinylated Cynomolgus / Rhesus macaque FcRn Heterodimer Protein, His, Avitag&Streptavidin II Tag (FCM-C82W5) is expressed from human HEK293 cells. It contains AA Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M) (Accession # Q8SPV9-1 (FCGRT) & Q8SPW0-1 (B2M)). In the region Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M), the AA sequence of Cynomolgus and Rhesus macaque FcRn (FCGRT & B2M) are homologus.
Background
FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
Molecule
FcRn (FCGRT & B2M)
Exp Region
Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M)
Characteristics
Biotinylated Cynomolgus / Rhesus macaque FcRn Heterodimer Protein, His, Avitag&Streptavidin II Tag, produced by co-expression of FCGRT and B2M, has a calculated MW of 34.1 kDa (FCGRT) and 13.0 kDa (B2M). Subunit FCGRT is fused with an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag and subunit Beta-2 microglobulin (B2M) is fused with a Streptavidin II tag at the C-terminus. The reducing (R) protein migrates as 40 kDa (FCGRT) and 14 kDa (B2M) respectively due to glycosylation.
Endotoxin
1.0 EU per μg
Buffer
PBS, pH7.4
Stability
● -20°C to -70°C for 12 months in lyophilized state
● -70°C for 12 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 25 ug
Available: In stock
available

Delivery expected until 2/12/2026 

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