Comparison

Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (SPR & BLI & HPLC-verified) European Partner

Item no. FCM-H5286-50ug
Manufacturer ACROBiosystems
Amount 50 ug
Quantity options 500 ug x 2 50 ug
Category
Type Proteins Recombinant
Format Solid
Specific against Human (Homo sapiens)
Host HEK293
Conjugate/Tag Unconjugated, Strep II, HIS
Purity 95%
Citations (1) Goebl NA., et al., 2008, Mol. Biol. Cell 19 (12): 5490-505. (2) Lee TY., et al., 2008, Clin. Cancer Res. 14 (5): 1487-93. (3) Güssow D., et al., 1987, J. Immunol. 139 (9): 3132-8. (4) Gorevic P.D., et al., 1986, Proc. Natl. Acad. Sci. U.S.A. 83:7908-7912.
NCBI NP_001129491.1 (FCGRT) , AAH32589.1 (B2M)
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias FcRn,FCGRT & B2M
Shipping Condition Room temperature
Available
Manufacturer - Category
Protein / MABSol® Fc Receptors
Manufacturer - Conjugate / Tag
C-6xHis | C-Strep II, Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
31.2 kDa (FCGRT) & 13.1 kDa (B2M)
Manufacturer - Format
Powder
Description
Human FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (FCM-H5286) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M) (Accession # P55899-1 (FCGRT) & P61769-1 (B2M)).
Background
FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
Molecule
FcRn (FCGRT & B2M)
Exp Region
Ala 24 - Ser 297 (FCGRT) & Ile 21 - Met 119 (B2M)
Characteristics
Human FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag, produced by co-expression of FCGRT and B2M, has a calculated MW of 31.2 kDa (FCGRT) and 13.1 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at the C-terminus and subunit Beta-2 microglobulin (B2M) is fused with Strep II-tag at the C-terminus. The reducing (R) protein migrates as 33 kDa (FCGRT) and 13 kDa (B2M) respectively due to glycosylation.
Endotoxin
1.0 EU per μg
Buffer
PBS, pH 7.4
Stability
● -20°C to -70°C for 12 months in lyophilized state;
● -70°C for 12 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50 ug
Available: In stock
available

Delivery expected until 8/28/2025 

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