sAPPalpha ELISA Kits (human, mouse, rat, rabbit)

Sodium Azide (0.1%)

sAPPalpha is the extracellular soluble fragment of amyloid precursor protein cleaved by "alpha-secretase." Generation of sAPPalpha by "alpha-secretase" prevents development of fibrillogenic amyloid-beta since the cleavage site is within the amyloid-beta molecule. The generation of sAPPalpha may therefore be neuroprotective. sAPPalpha may function in neuronal excitability, synaptic plasticity, neurite outgrowth, synaptogenesis, and cell survival. sAPPalpha also appears to modulate potassium channels, N-methyl-D-aspartate receptors, and the transcription factor NF kappa B1.

1. Lopez-Perez E, Dumanchin C, Czech C, Campion D, Goud B, et al. 2000. Overexpression of Rab11 or constitutively active Rab11 does not affect sAPPalpha and Abeta secretions by wild-type and Swedish mutated betaAPP-expressing HEK293 cells. Biochem Biophys Res Commun 275: 910-5

2. Maillet M, Robert SJ, Cacquevel M, Gastineau M, Vivien D, et al. 2003. Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha. Nat Cell Biol 5: 633-9

3. Mousavi M, Hellstrom-Lindahl E. 2009. Nicotinic receptor agonists and antagonists increase sAPPalpha secretion and decrease Abeta levels in vitro. Neurochem Int 54: 237-44

4. Siemes C, Quast T, Klein E, Bieber T, Hooper NM, Herzog V. 2004. Normalized proliferation of normal and psoriatic keratinocytes by suppression of sAPPalpha-release. J Invest Dermatol 123: 556-63

5. Smirnov A, Trupp A, Henkel AW, Bloch E, Reulbach U, et al. 2009. Differential processing and secretion of Abeta peptides and sAPPalpha in human platelets is regulated by thrombin and prostaglandine 2. Neurobiol Aging 30: 1552-62

6. Talamagas AA, Efthimiopoulos S, Tsilibary EC, Figueiredo-Pereira ME, Tzinia AK. 2007.

Abeta(1-40)-induced secretion of matrix metalloproteinase-9 results in sAPPalpha release by association with cell surface APP. Neurobiol Dis 28: 304-15