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Human GCGR/Glucagon receptor Protein-VLP (GCR-HM00V)

Human GCGR/Glucagon receptor Protein-VLP (GCR-HM00V)

Item no.	GCR-HM00V-100UG
Manufacturer	KactusBio
Amount	100 ug
Category	Metabolism Diabetes Glucose Homeostasis
Format	Liquid
Specific against	Human (Homo sapiens)
Host	HEK293
Purity	> 95% as determined by HPLC
Dry ice	Yes
Sequence	Met1-Phe477
Alias	Glucagon receptor,GL-R,GCGR,Glucagon R
Shipping Condition	Dry ice
Available
Manufacturer - Type	Recombinant Protein
Manufacturer - Targets	GCGR
Shipping Temperature	Shipped with dry ice.
Storage Conditions	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Molecular Weight	The target protein has a predicted MW of 56 kDa.
Description	Recombinant Human GCGR/Glucagon receptor Protein-VLP is expressed from HEK293.It contains Met1-Phe477 (It may have cross reaction with anti-His antibody).
Background	The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed at the plasma membrane is constitutively ubiquitinated and upon agonist-activation, internalized GCGRs are deubiquitinated at early endosomes and recycled via Rab4-containing vesicles.
Endotoxin	Less than 1 EU per μg by the LAL method.
Formulation	Supplied as 0.22μm filtered solution in PBS, 150mM L-Arginine (pH 7.4). Notice: If you need it for immunization, water-soluble adjuvant is recommended.
Biotinylated	no

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

GCR-HM00V-100UG-datasheet.pdf

GCR-HM00V-100UG-safety-datasheet.pdf