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Biotinylated Human GCGR/Glucagon receptor Protein-Nanodisc (GCR-HM10NB)

Biotinylated Human GCGR/Glucagon receptor Protein-Nanodisc (GCR-HM10NB)

Item no.	GCR-HM10NB-100UG
Manufacturer	KactusBio
Amount	100 ug
Category	Metabolism Diabetes Glucose Homeostasis
Format	Liquid
Specific against	Human (Homo sapiens)
Host	HEK293
Conjugate/Tag	HIS
Dry ice	Yes
Sequence	Met1-Phe477
Alias	Glucagon receptor,GL-R,GCGR,Glucagon R
Shipping Condition	Dry ice
Available
Manufacturer - Type	Recombinant Protein
Manufacturer - Targets	GCGR/Glucagon receptor
Manufacturer - Conjugate / Tag	C-His
Shipping Temperature	Shipped with dry ice.
Storage Conditions	Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Molecular Weight	The protein has a predicted MW of 66.9 kDa.
Description	Recombinant Biotinylated Human GCGR/Glucagon receptor Protein-Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Phe477.
Background	The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed at the plasma membrane is constitutively ubiquitinated and upon agonist-activation, internalized GCGRs are deubiquitinated at early endosomes and recycled via Rab4-containing vesicles.
Endotoxin	Less than 1 EU per μg by the LAL method.
Formulation	Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Biotinylated	yes

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

GCR-HM10NB-100UG-datasheet.pdf

GCR-HM10NB-100UG-safety-datasheet.pdf