Serum Amyloid P Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-Serum Amyloid P Polyclonal Antibody is specific to human and mouse serum amyloid P component. It has not yet been tested in other species.

Serum amyloid P component (SAP) is a non-fibrillar plasma glycoprotein that belongs to the pentraxin family. It is universally found in amyloid deposits (such as senile plaque and neurofibrially tangles in Alzheimers patients), and this is probably due to its specific calcium-dependent binding to motifs, which are present on all types of amyloid fibrils. SAP is also found to prevent fibrillar breakdown by enzymes and it is believed that it helps maintains stability of the amyloid deposits. It has been shown that SAP binds monocytes with high avidity, but does not bind to erythrocytes, NK cells, T-lymphocytes, or B-lymphocytes. SAP production can be induced by exposure to IL-1, IL-6, and IFN-beta. SAP levels in CSF can be useful for assessing cognitive impairment in AD patients. GenScript, Rabbit Anti-Serum Amyloid P Polyclonal Antibody, is developed in rabbit using a synthetic peptide corresponding to residues near the N-terminus of human serum amyloid P-component conjugated to KLH.

Immunoaffinity chromatography