GPR30 Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-GPR30 Polyclonal Antibody detects endogenous levels of human GPR30 protein.

GPR30 (G Protein-coupled Receptor 30), also known as G Protein-coupled estrogen Receptor 1 (GPER), is a member of G protein-coupled receptor family. It contains seven hydrophobic transmembrane domains embedded in hydrophilic intra- and extracellular loops. GPR30 transduces a variety of hormone, endogenous peptide, and neurotransmitter signals into intracellular effects via G proteins. GPR30 is an orphan receptor and localizes to the endoplasmic reticulum, where it specifically binds estrogen and estrogen derivatives. Activating GPR30 via estrogen results in intracellular calcium mobilization and synthesis of phosphatidylinositol 3, 4, 5-trisphosphate in the nucleus. GenScript, Rabbit Anti-GPR30 Polyclonal Antibody, is developed in rabbit using a KLH-coupled synthetic peptide from amino terminal of human GPR30 protein (Swiss Prot: Q99527).

Immunoaffinity chromatography

Small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage. Before use, briefly centrifuge the vial to dislodge any liquid in the container's cap.