PIN1 Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-PIN1 Polyclonal Antibody detects human PIN1 protein. Sequence homology predicts that it will also react with rat and mouse PIN1 proteins.

PIN1 is an essential peptidyl-prolyl isomerase that regulates mitosis, presumably by interacting with NIMA and attenuating its mitosis-promoting activity. It displays a preference for an acidic residue N-terminal to the isomerized proline bond. It catalyzes pSer/Thr-Pro cis/trans isomerizations. PIN1 has been implicated in tau pathologies that underlie Alzheimer's disease. PIN1 binds to tau-phosphorylated sites, specifically on the Thr231-Pro site, where it induces conformational changes. PIN1 may be pivotal in maintaining normal neuronal function and preventing age-dependent neurodegeneration. GenScript, Rabbit Anti-PIN1 Polyclonal Antibody, is developed in rabbit hosts using a KLH-coupled synthetic peptide within residues 50-100 of human PIN1 protein (Swiss Prot: Q13526).

Immunoaffinity chromatography

57 kD

Small volumes of antibody will occasionally become trapped in the seal of the product vial during shipment and storage. Before use, briefly centrifuge the vial to dislodge any liquid in the container's cap.