Calreticulin Antibody, pAb, Rabbit

USA

GenScript Rabbit Anti-Calreticulin Polyclonal Antibody detects endogenous levels of human Calreticulin. It is predicted to react with mouse and rat Calreticulin according to sequence homology. Positive Control: Hela and HepG2

Calreticulin is a multifunctional protein that serves as a major Ca2+-binding protein in the lumen of the endoplasmic reticulum. It binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of nuclear receptors. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin also serves as a recognition and clearance ligand by activating the internalization receptor LRP1 on the responding phagocyte cell surface. GenScript, Rabbit Anti-Calreticulin Polyclonal Antibody, is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human Calreticulin (Swiss Prot: P27797).

Immunoaffinity chromatography.