UBE3A antibody, pAb, Rabbit

USA

UBE3A Antibody, detects endogenous levels of human and mouse UBE3A. Positive Control: Hela, A549, HepG2, HT29 and mouse brain tissue

UBE3A (Ubiquitin protein ligase E3A) is one member of the E3 ubiquitin-protein ligase family which plays a role in defining the substrate specificity of the ubiquitin-proteasome degradation system. UBE3A can interact directly with the growth and tumor-suppressive protein, p53 or indirectly as part of a human papillomavirus type 16 or 18 E6 protein complex. Mutations within the UBE3A gene are responsible for some cases of Angelman syndrome. Alternative splicing of UBE3A gene results in three transcript variants encoding three isoforms with different N-termini. GenScript, UBE3A antibody, is developed in rabbit using a KLH-coupled synthetic peptide from N-terminal of human UBE3A (Swiss Prot: Q05086).

Immunoaffinity chromatography

75 KD