Human CD38 Antibody (38.H1), mAb, Mouse

USA

The lyophilized product remains stable up to 1 year at -20 C from date of receipt. Upon reconstitution, it can be stored for 2-3 weeks at 2-8 C or for up to 12 months at -20 C or below. Avoid repeated freezing and thawing cycles.

CD38 glycoprotein is a particularly attractive target on malignant plasma cells at all stages of disease and in Chronic lymphocytic leukemia (also called CLL) patients with a poor clinical prognosis. It is highly expressed in lymphoid tumors including multiple myeloma, AIDS-associated lymphomas, and post-transplant lymphoproliferation. In contrast, the molecule is detectable only at very low levels in mature lymphocytes or in nonhematopoietic tissues. Therapeutic Anti-CD38 antibodies (e.g. Daratumumab) can induce strong antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity to kill tumors.
GenScript Human CD38 Antibody (38.H1), mAb, Mouse is produced from a hybridoma resulting from the fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with recombinant human CD38.