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Interleukin-8 (IL-8)/CXCL8 (8-79aa), Human

Interleukin-8 (IL-8)/CXCL8 (8-79aa), Human

Item no.	Z02195-50
Manufacturer	GenScript
Amount	50 ug
Quantity options	10 ug 50 ug
Category	Oncology Food Safety Neuroscience Neuroinflammation Metabolism Diabetes By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Adhesion Contaminants Cell Migration & Invasion Metals By Organ Breast Cancer Heart & Blood Cancer
Type	Proteins
Specific against	Human (Homo sapiens)
Purity	Greater than 95.0% as determined by (a) Analysis by RP-HPLC (b) Analysis by reducing and non-reducing SDS-PAGE silver stained gel
Sequence	The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Ala-Lys-Glu-Leu.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02195_50-Interleukin_8_IL_8_8_79_Human,Interleukin-8 (IL-8), belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states. GenScript, human Interleukin-8 (IL-8) (8-79), produced in, E. coli, is a single, non-glycosylated polypeptide chain containing 72 amino acids and having a molecular mass of 8,452 Da.</td></tr><tr><th>M.W.</th><td colspan="7"> 8,000 Da+/-10% determined by reduced SDS-PAGE</td></tr><tr><th>Purity</th><td colspan="7"> Greater than 95.0% as determined by (a) Analysis by RP-HPLC (b) Analysis by reducing and non-reducing SDS-PAGE silver stained gel</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> Less than 0.1ng/ug (1 EU/ug) determined by LAL test.</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized recombinant Interleukin-8 (IL-8) (8-79) although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution recombinant Interleukin-8 (IL-8) (8-79) should be stored at 4C between 2-7 days and for future use below -18C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.</td></tr><tr><th>Specificity</th><td colspan="7"> Recombinant human Interleukin-8 (IL-8) (8-79) is fully biologically active when compared to standard. The ED50 as determined by its chemotaxis of hCXCR-2 transfected mouse BaF/3 cells is less then 0.5 ng/ml, corresponding to a specific activity of 2.0×106 IU/mg.</td></tr><tr><th>Formulation</th><td colspan="7"> The protein was lyophilized after extensive dialysis against PBS, pH7.4.</td></tr><tr><th>Reconstitution</th><td colspan="7"> It is recommended to reconstitute the lyophilized recombinant human Interleukin-8 (IL-8) (8-79) in sterile 18 M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.</td></tr><tr><th>Sequence</th><td colspan="7"> The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Ala-Lys-Glu-Leu.</td></tr>
Similar products	Interleukin-8
Available
Specificity	Recombinant human Interleukin-8 (IL-8) (8-79) is fully biologically active when compared to standard. The ED50 as determined by its chemotaxis of hCXCR-2 transfected mouse BaF/3 cells is less then 0.5 ng/ml, corresponding to a specific activity of 2.0x106
Country of Origin	USA
Storage Conditions	Lyophilized recombinant Interleukin-8 (IL-8) (8-79) although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution recombinant Interleukin-8 (IL-8) (8-79) should be stored at 4C between 2-7 days and for future use below -18C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.
Molecular Weight	8, 000 Da+/-10% determined by reduced SDS-PAGE
Product Line	Cytokine, Chemokines & Growth Factors
Manufacturer - Specificity	Recombinant human Interleukin-8 (IL-8) (8-79) is fully biologically active when compared to standard. The ED50 as determined by its chemotaxis of hCXCR-2 transfected mouse BaF/3 cells is less then 0.5 ng/ml, corresponding to a specific activity of 2.0x106 IU/mg.
Description	Interleukin-8 (IL-8), belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states. GenScript, human Interleukin-8 (IL-8) (8-79), produced in, E. coli, is a single, non-glycosylated polypeptide chain containing 72 amino acids and having a molecular mass of 8, 452 Da.
Reconstitution	It is recommended to reconstitute the lyophilized recombinant human Interleukin-8 (IL-8) (8-79) in sterile 18 M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Formulation	The protein was lyophilized after extensive dialysis against PBS, pH7.4.
Endotoxin Level	Less than 0.1ng/ug (1 EU/ug) determined by LAL test.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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