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VEGF165, Human

VEGF165, Human

Item no.	Z02689-1
Manufacturer	GenScript
Amount	1 mg
Quantity options	1 mg 10 ug 100 ug 50 ug
Category	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Molecular Targets for Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Neural Development By Cell Type Blastoma Carcinoma Hematology Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Adhesion Cell Culture Cytokines Cell Status Adenocarcinoma Cell Metabolism Oxidative Stress By Organ Bladder Cancer Colorectal Cancer
Type	Proteins
Specific against	Human (Homo sapiens)
Purity	> 95% as analyzed by reducing SDS-PAGE.
Sequence	Ala27-Arg191 (accession number:P15692).
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02689_1-VEGF_A165_Human,Vascular Endothelial Growth Factor (VEGF), is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, Vascular Endothelial Growth Factor (VEGF) plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates Vascular Endothelial Growth Factor (VEGF) in the induction of tumor metastasis and intra-ocular neovascular syndromes. Vascular Endothelial Growth Factor (VEGF) signals through the three receptors, fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product.Recombinant, human Vascular Endothelial Growth Factor A165 (rhVEGF-A165), produced in Pichia pastoris is a disulfide-linked homodimer containing two polypeptide chains of 165 amino acids each. A fully biologically active molecule, rhVEGF-A165 has a molecular mass of 38.2kDa analyzed by non-reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.</td></tr><tr><th>M.W.</th><td colspan="7">38.2kDa, observed by non-reducing SDS-PAGE</td></tr><tr><th>Purity</th><td colspan="7">> 95% as analyzed by reducing SDS-PAGE.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> <0.5 EU/ug, determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> ED50 of 1-5ng/ml, measured by the dose-dependent stimulation of the proliferation of HUVEC cells, corresponding to a specific activity of 2x 105-1x 106 units/mg.</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized recombinant, human Vascular Endothelial Growth Factor A165 (rhVEGF-A165), remains stable up to 12 months at -80C from date of receipt. Upon reconstitution, rhVEGF-A165 should be stable up to 4 week at 4C or up to 6 months at -20C.</td></tr><tr><th>Formulation</th><td colspan="7">Lyophilized after extensive dialysis against 25 mM HEPES and 150 mM NaCl, pH 7.0.</td></tr><tr><th>Reconstitution</th><td colspan="7"> Reconstituted in ddH2O at 100 ug/ml.</td></tr><tr><th>Sequence</th><td colspan="7"> Ala27-Arg191 (accession number:P15692).</td></tr>
Similar products	VEGF-A165
Shipping Condition	Cool pack
Available
Specificity	ED50 of 1-5ng/ml, measured by the dose-dependent stimulation of the proliferation of HUVEC cells, corresponding to a specific activity of 2x 105-1x 106 units/mg.
Manufacturer - Category	Proteins
Country of Origin	USA
Shipping Temperature	4°C
Storage Conditions	-80°C
Molecular Weight	38.2kDa, observed by non-reducing SDS-PAGE
Product Line	Growth Factors
Manufacturer - Specificity	ED50 of 1-5ng/ml, measured by the dose-dependent stimulation of the proliferation of HUVEC cells, corresponding to a specific activity of 2x 105-1x 106 units/mg.
Description	Vascular Endothelial Growth Factor (VEGF), is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, Vascular Endothelial Growth Factor (VEGF) plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates Vascular Endothelial Growth Factor (VEGF) in the induction of tumor metastasis and intra-ocular neovascular syndromes. Vascular Endothelial Growth Factor (VEGF) signals through the three receptors, fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product.Recombinant, human Vascular Endothelial Growth Factor A165 (rhVEGF-A165), produced in Pichia pastoris is a disulfide-linked homodimer containing two polypeptide chains of 165 amino acids each. A fully biologically active molecule, rhVEGF-A165 has a molecular mass of 38.2kDa analyzed by non-reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Reconstitution	Reconstituted in ddH2O at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against 25 mM HEPES and 150 mM NaCl, pH 7.0.
Endotoxin Level	<0.5 EU/ug, determined by LAL method.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mg

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Delivery expected until 8/7/2025

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