GM-CSF, Human

USA

-80°C

Growth Factors

Human Granulocyte Macrophage Colony Stimulating Factor (hGM-CSF) , a hematopoietic growth factor, is mainly involved in granulopoiesis and monocytopoiesis. It is produced by T-cells and macrophages in response to antigens, and by endothelial cells and fibroblasts following induction of variouscytokines [1]. A monomeric protein of 127 amino acidswith six glycosylation sites and two intra disulfide bonds[2, 3], glycosylated and non-glycosylated hGM-CSFs show similar biological activities[4]. Other than its connection to the growth and development of granulocytes and macrophages, it is also indispensable for the proliferation of erythroid and megakaryocytic cells[5]. Recombinant, Human Granulocyte Macrophage Colony Stimulating Factor (rhGM-CSF), produced in, E.coli, a glycosylated polypeptide. A fully biologically active molecule, rhGM-CSF has a molecular mass of 26-32kDa analyzed by SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques at GenScript.

Lyophilized after extensive dialysis against 10 mM PB, pH7.0.

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