MIP-3/CCL23, Human

This lyophilized preparation is stable at 2-8 C, but should be kept at -20 C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 C to -70 C. Avoid repeated freeze/thaw cycles.

Cytokine, Chemokines & Growth Factors

MIP-3/CCL23 is a CC chemokine that signals through the CCR1 receptor. MIP-3 chemoattracts monocytes, resting T-lymphocytes and neutrophils, but does not chemoattract activated lymphocytes. Additionally, MIP-3 has been shown to inhibit colony formation of bone marrow myeloid immature progenitors. Alternative splicing of the MPIF1 gene results in two mRNAs that encode a short (CKß8) and a long (CKß81) isoform of the chemokine. CKß8 cDNA encodes a 120 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide that is cleaved to generate a 99 aa residue mature CKß8 (aa 22 120). Additional N terminal processing of the 99 aa residue variant can generate a 75 aa residue CKß8 (aa 46 120) that is significantly more active than the 99 aa residue variant.

Lyophilized from a 0.2µ, m filtered concentrated solution in 20mM PB, pH 7.4, 150mM NaCl.

This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.