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IGF-BP-3, Human

IGF-BP-3, Human

Manufacturer	GenScript
Category	Oncology Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite By Cell Type Carcinoma Hematology Leukemia Sarcoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines Cell Status Apoptosis Cytoskeleton Endocrine Regulation of Lipid Metabolism By Organ Lung Cancer Other Lipid\Cholesterol Metabolism Modulators small GTPases Rab Subfamily
Type	Proteins
Specific against	Human
Format	Sterile Filtered White lyophilized (freeze-dried) powder.
Amount	1 mg
Item no.	Z02862-1
Targets	GPBAR1, IFT27, IGF2, IGF1, DNTT, GRP
eClass 6.1	34160400
eClass 9.0	42020190
Available
Specificity	Fully biologically active when compared to standard. The ED50 determined by inhibiting IGF-II induced proliferation ofserum free human MCF-7 cells is less than 200 ng/ml, corresponding to a specific activity of 5.0 x 103 IU/mg in the presence of 15ng/ml of rHuIGF-II.
Description	IGF-BP3 is a 30 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals and it is also found in ª-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF.
Endotoxin Level	Less than 0.2EU/ug of rHuIGF-BP3 as determined by LAL method.
Formulation	Lyophilized from a 0.2um filtered concentrated solution in PBS, pH 7.4.
M.W.	28.8 kDa protein consisting of 264 amino acid residues.
Product Line	Cytokine, Chemokines & Growth Factors
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at < -20 C. Further dilutions should be made in appropriate buffered solutions.
Storage	This lyophilized preparation is stable at 2-8 C, but should be kept at -20 C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 C to -70 C. Avoid repeated freeze/thaw cycles.
Usage	This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Manufacturers Category	Proteins
Manufacturers Product Line	Growth Factors
Product Origin	USA

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 mg

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Delivery expected until 6/6/2024