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IFN-γ, Human

IFN-γ, Human

Item no.	Z02915-50
Manufacturer	GenScript
Amount	50 ug
Quantity options	1 mg 10 ug 100 ug 50 ug
Category	Oncology Neuroscience Neuroinflammation By Cell Type Carcinoma Hematology Myeloma Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines Cell Status Apoptosis Cardiovascular Research Ischemia & Reperfusion Injury Toxicity & Cytotoxicity Hypertension
Type	Proteins
Specific against	Human (Homo sapiens)
Purity	> 95% as analyzed by reducing SDSPAGE.
Citations	Trinchieri, G.(2010) J Exp Med. 207:2053–63. Ealick, S.E. et al.(1991) Science. 252:698–702. Schroder, K. et al.(2004) J Leukoc Biol.75:163–89. Hu, X. et al. (2008) Immunol Rev. 226: 41–56. Wischhusen, J. et al.(2007) Semin Cancer Biol. 17:459–68.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02915_50-Interferon_gamma_IFN_gamma_Human, Human Interferon gamma (hIFN-gamma) is amacrophageactivating factor and the lone member of Interferon type II.The active form of IFN-gamma is an antiparallel dimer that interacts with the receptor IFN-gammaR1 and sets off IFN-gamma/JAK/STAT pathway. IFN-gamma signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity. While IFN-gamma–induced inflammatory cascade summons a variety of immunerelated cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-gamma is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers. Recombinant human Interferon gamma (rhIFN-gamma) produced in, E. coli, is a nonglycosylated polypeptide chain of 144 amino acids. A fully biologically active molecule, rhIFN-gamma has a molecular mass of 17 kDa analyzed by reducing SDSPAGE and is obtained by proprietary refolding and chromatographic techniques at GenScript.</td></tr><tr><th>M.W.</th><td colspan="7"> 17kDa, observed by reducing SDSPAGE.</td></tr><tr><th>Purity</th><td colspan="7"> > 95% as analyzed by reducing SDSPAGE.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> <1 EU/ug, determined by LAL</td></tr><tr><th>Specific Activity</th><td colspan="7"> ED50<0.05ng/ml, measured bycytotoxicity assay using HT29 cells.</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized recombinant human Interferon gamma (rhIFNgamma) remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhIFN-gamma should be stable up to 1 week at 4C or up to 2 months at -20C.</td></tr><tr><th>Formulation</th><td colspan="7"> Lyophilized after extensive dialysis against PBS.</td></tr><tr><th>Reconstitution</th><td colspan="7"> Reconstituted in ddH2O or PBS at 100 ug/ml.</td></tr><tr><th>Reference</th><td colspan="7">Trinchieri, G.(2010) J Exp Med. 207:2053–63. Ealick, S.E. et al.(1991) Science. 252:698–702. Schroder, K. et al.(2004) J Leukoc Biol.75:163–89. Hu, X. et al. (2008) Immunol Rev. 226: 41–56. Wischhusen, J. et al.(2007) Semin Cancer Biol. 17:459–68.</td></tr>
Similar products	Interferon-gamma
Shipping Condition	Cool pack
Available
Specificity	ED50<0.05ng/ml, measured bycytotoxicity assay using HT29 cells.
Manufacturer - Category	Proteins
Country of Origin	USA
Shipping Temperature	4°C
Storage Conditions	-80°C
Molecular Weight	17kDa, observed by reducing SDSPAGE.
Product Line	Cytokines
Manufacturer - Specificity	ED50<0.05ng/ml, measured bycytotoxicity assay using HT29 cells.
Description	Human Interferon gamma (hIFN-gamma) is amacrophageactivating factor and the lone member of Interferon type II.The active form of IFN-gamma is an antiparallel dimer that interacts with the receptor IFN-gammaR1 and sets off IFN-gamma/JAK/STAT pathway. IFN-gamma signaling does diverse biological functions primarily related to host defense and immune regulation, including antiviral and antibacterial defense, apoptosis, inflammation, and innate and acquired immunity. While IFN-gamma–induced inflammatory cascade summons a variety of immunerelated cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-gamma is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers. Recombinant human Interferon gamma (rhIFN-gamma) produced in, E. coli, is a nonglycosylated polypeptide chain of 144 amino acids. A fully biologically active molecule, rhIFN-gamma has a molecular mass of 17 kDa analyzed by reducing SDSPAGE and is obtained by proprietary refolding and chromatographic techniques at GenScript.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Endotoxin Level	<1 EU/ug, determined by LAL

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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