Interleukin-17 Receptor D (IL-17 RD), Mouse

USA

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Interleukin-17 receptor D (IL-17RD) , also known as similar expression to the fibroblast growth factor receptor (SEF), is a member of the interleukin-17 receptor family. Studies indicate that IL-17RD interacts with IL-17R to facilitate IL-17 signaling. Additionally, IL-17RD may play an important role in preventing certain types of cancer. Studies suggest that IL-17D acts as a feedback inhibitor of fibroblast growth factor-mediated MAPK signaling and ERK activation. Studies indicate that IL-17D can bind to MEK/ERK complexes preventing nuclear ERK translocation and subsequent cell proliferation.
Recombinant Mouse IL-17 RD produced in CHO cells is a polypeptide chain containing 271 amino acids. A fully biologically active molecule, rmIL-17 RD has a molecular mass of 53-56 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.