SIRPα Fc Chimera, Human

USA

-80°C

Signal regulatory protein alpha (SIRPalpha, designated CD172a), is also known as CD172 antigen-like family member A (CD172a), also called SHPS-1 (SHP substrate 1) and previously, MyD-1 (Myeloid/Dendritic-1), which is a monomeric about 90kDa type I transmembrane glycoprotein that belongs to the SIRP/SHPS (CD172) family of the immunoglobulin superfamily. SIRPalpha is Ubiquitous and highly expressed in brain. SIRPA/CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA/SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function by similarity. SIRPalpha recognition of surfactants SP-A and SP-D in the lung can inhibit alveolar macrophage cytokine production. Recombinant Human SIRPalpha Fc Chimera produced in HEK293 cells is a polypeptide chain containing 572 amino acids with the C-termimal human IgG1 Fc fragment. A fully biologically active molecule; rhSIRPalpha a molecular mass of 85-100 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.