Beta-Defensin 4 (BD-4), Rat

This lyophilized preparation is stable at 2-8C, but should be kept at -20C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20C to -70C. Avoid repeated freeze/thaw cycles.

Cytokine, Chemokines & Growth Factors

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four rat beta-defensins have been identified, BD-1, BD-2, BD-3 and BD-4. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence. beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. beta-defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. BD-4 is expressed in testis, stomach, uterus, neutrophils, thyroid, lung and kidney.

Lyophilized from a 0.2 um filtered concentrated solution in 10 mM PB, pH 7.4, 500mM NaCl.