Interferon gamma (IFN-gamma), Rat

USA

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Interferon gamma (IFN-gamma), also known as Type II interferon, is a cytokine produced primarily by T-lymphocytes and natural killer cells. The active form of IFN-gamma is an antiparallel dimer that interacts with the receptor IFN-gammaR1 and activates the IFN-gamma/JAK/STAT pathway. IFN-gamma signaling promotesbiological functions primarily related to antiviral and antibacterial defense, apoptosis, inflammation, and regulation of innate and acquired immune responses. While IFN-gamma–induced inflammatory cascades summon a variety of immune-related cell types, such as macrophages, natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), IFN-gamma is also implicated in resistance to NK cell and CTL responses and in immune escape in a variety of cancers.
Recombinant Rat Interferon gamma (IFN-gamma) produced in E.coli is a single non-glycosylated polypeptide chain containing 134 amino acids. A fully biologically active molecule, rrIFN-gamma has a molecular mass of 15.5 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.