RABBIT ANTI HUMAN PIB5PA (N-TERMINAL)

PIB5PA (N-TERMINAL)

Phosphate buffered saline pH7. 7

Synthetic Peptide corresponding to the N-Terminal domain of Human PIPB5PA conjugated to keyhole limpet hemocyanin (KLH).

Inositol 5-phosphatase which converts inositol 1 4 5-trisphosphate to inositol 1 4-bisphosphate. Also converts phosphatidylinositol 4 5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1 3 4 5-tetrakisphosphate to inositol 1 3 4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles By similarity. Catalytic activityD-myo-inositol 1 4 5-trisphosphate + H2O = myo-inositol 1 4-bisphosphate + phosphate. 1D-myo-inositol 1 3 4 5-tetrakisphosphate + H2O = 1D-myo-inositol 1 3 4-trisphosphate + phosphate. Subcellular locationCytoplasm By similarity.

The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein. Sequence similaritiesBelongs to the inositol-1 4 5-trisphosphate 5-phosphatase type II family. Sequence cautionThe sequence AAD15618. 1 differs from that shown. Reason: Erroneous gene model prediction. 1. Favaloro E. J. et al. (1987) Characterisation of monoclonal antibodies to the human myeloid-specific antigen \' gp67\' (CD-33). Dis Markers. 5: 215-225. 2. Favaloro E. J. et al. (1988) Further characterisation of myeloid antigens (\' gp160 95\' \' gp150\' and \' gp67\' ): Investigation of epitopic heterogeneity and non-haemopoietic distribution using panels of monoclonal antibodies belonging to CD-11b CD-13 and CD33. Br. J. Haematol. 69: 163-171. [1] \" Isolation of a cDNA encoding CD33 a differentiation antigen of myeloid progenitor cells. \" Simmons D. Seed B. J. Immunol. 141:2797-2800(1988) [PubMed: 3139766] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANT GLY-69. Tissue: Premonocytic lymphoma. [2] \" Genomic organization of the siglec gene locus on chromosome 19q13. 4 and cloning of two new siglec pseudogenes. \" Yousef G. M. Ordon M. H. Foussias G. Diamandis E. P. Gene 286:259-270(2002) [PubMed: 11943481] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [3] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] VARIANT GLY-69. Tissue: Leukocyte. [4] \" Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. \" Freeman S. D. Kelm S. Barber E. K. Crocker P. R. Blood 85:2005-2012(1995) [PubMed: 7718872] [Abstract]Cited for: SIALIC ACID-BINDING. [5] \" The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. \" Ulyanova T. Blasioli J. Woodford-Thomas T. A. Thomas M. L. Eur. J. Immunol. 29:3440-3449(1999) [PubMed: 10556798] [Abstract]Cited for: FUNCTION PHOSPHORYLATION AT TYR-340 AND TYR-358 MUTAGENESIS OF TYR-358 INTERACTION WITH PTPN6. [6] \" The myeloid-specific sialic acid-binding receptor CD33 associates with the protein-tyrosine phosphatases SHP-1 and SHP-2. \" Taylor V. C. Buckley C. D. Douglas M. Cody A. J. Simmons D. L. Freeman S. D. J. Biol. Chem. 274:11505-11512(1999) [PubMed: 10206955] [Abstract]Cited for: PHOSPHORYLATION AT TYR-340 AND TYR-358 INTERACTION WITH PTPN6 AND PTPN11 MUTAGENESIS OF TYR-340. [7] \" Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells. \" Vitale C. Romagnani C. Puccetti A. Olive D. Costello R. Chiossone L. Pitto A. Bacigalupo A. Moretta L. Mingari M. C. Proc. Natl. Acad. Sci. U. S. A. 98:5764-5769(2001) [PubMed: 11320212] [Abstract]Cited for: FUNCTION.