PTGS1 (prostaglandin-endoperoxide synthase 1)

Polyclonal antibody produced in rabbits immunized with a synthetic peptide corresponding to a region of Human PTGS1. Western Blot: Suggested dilution at 5. 0 microg/ml in 5% skim milk / PBS buffer. and HRP conjugated anti-Rabbit IgG should be diluted in 1: 50. 000 - 100. 000 as second antibody.

Signal Protein

May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.

Lipid metabolism; prostaglandin biosynthesis.

Microsome membrane; Peripheral membrane protein.

This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin.

Contains 1 EGF-like domain. Summary: Prostaglandin-endoperoxide synthase (PTGS) also known as cyclooxygenase is the key enzyme in prostaglandin biosynthesis and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2 which differ in their regulation of expression and tissue distribution. This protein is PTGS1 which regulates angiogenesis in endothelial cells and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. Chubb. A. J. . (2006) Biochemistry 45 (3). 811-820.