MOUSE ANTI HUMAN CD47

Manufacturer GENWAY
Category
Type Antibody
Specific against Human
Applications IP
Amount 0.1 mg
Host Mouse
ArtNr 20-783-314617
Available
Genway ID:
GWB-476779
Specificity:
CD47
Isotype:
IgG2b
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgG concentration 1. 0mg/ml
Immunogen:
Human erythrocytes.
Specificity:
Is specific for human CD47 also known as integrin-associated protein a 50kDa glycoprotein expressed on all haematopoietic cell lines epithelial cells endothelial cells fibroblasts and many tumour cell lines. CD47 is involved in several cellular processes including regulation of T cell and dendritic cell activation regulation of neutrophil (PMN) chemotaxis caspase-independent apoptosis and may act as a signal transducer in the regulation of cation fluxes across cell membranes. CD47 has been identified as a ligand for the inhibitory macrophage receptor known as signal regulatory protein alpha (SIRPalpha) and as a receptor for thrombospondin-1. Cross-linking of CD47 with clone 1/1A4 co-stimulates the proliferation of T cells (1). Recommended Negative Controls: MOUSE IgG2b NEGATIVE CONTROLRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGRabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgGGoat Anti Mouse IgG IgA IgMRabbit Anti Mouse IgGHuCAL Anti Mouse IgG2bGoat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)
Function:
Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus By similarity. Receptor for SIRPA binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. Ref. 2Ref. 10Ref. 12Subunit structureInteracts with THBS1 and fibrinogen By similarity. Monomer. Interacts with SIRPA SIRPG UBQLN1 and UBQLN2. Ref. 10Ref. 12Ref. 8Subcellular locationCell membrane; Multi-pass membrane proteinRef. 2. Tissue specificityVery broadly distributed on normal adult tissues as well as ovarian tumors being especially abundant in some epithelia and the brain. Sequence similaritiesContains 1 Ig-like V-type (immunoglobulin-like) domain. [1] \" Transcript mapping in a 46-kb sequenced region at the core of 12q13. 3 amplification in human cancers. \" Elkahloun A. G. Krizman D. B. Wang Z. Hofmann T. A. Roe B. A. Meltzer P. S. Genomics 42:295-301(1997) [PubMed: 9192850] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] ALTERNATIVE SPLICING (ISOFORM 2) VARIANT VAL-1124. [2] Roe B. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databasesCited for: SEQUENCE REVISION TO 389; 768-769; 1124; 1137 AND 1147 (ISOFORM 2). [3] \" GGAPs a new family of bifunctional GTP-binding and GTPase-activating proteins. \" Xia C. Ma W. Stafford L. J. Liu C. Gong L. Martin J. F. Liu M. Mol. Cell. Biol. 23:2476-2488(2003) [PubMed: 12640130] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) TISSUE SPECIFICITY SUBCELLULAR LOCATION FUNCTION. Tissue: Heart. [4] \" PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase preventing neuronal apoptosis. \" Rong R. Ahn J. -Y. Huang H. Nagata E. Kalman D. Kapp J. A. Tu J. Worley P. F. Snyder S. H. Ye K. Nat. Neurosci. 6:1153-1161(2003) [PubMed: 14528310] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). [5] \" Kiaa0167 as a member (centaurin gamma1) of centaurin ArfGAP family. \" Hong W. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). [6] \" Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. \" Nagase T. Seki N. Ishikawa K. Tanaka A. Nomura N. DNA Res. 3:17-24(1996) [PubMed: 8724849] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Bone marrow. [7] \" Complete sequencing and characterization of 21 243 full-length human cDNAs. \" Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. Kimura K. Makita H. Sekine M. Obayashi M. Nishi T. Shibahara T. Tanaka T. Ishii S. Yamamoto J. Saito K. Kawai Y. Isono Y. Nakamura Y. Nagahari K. Murakami K. Yasuda T. Iwayanagi T. Wagatsuma M. Shiratori A. Sudo H. Hosoiri T. Kaku Y. Kodaira H. Kondo H. Sugawara M. Takahashi M. Kanda K. Yokoi T. Furuya T. Kikkawa E. Omura Y. Abe K. Kamihara K. Katsuta N. Sato K. Tanikawa M. Yamazaki M. Ninomiya K. Ishibashi T. Yamashita H. Murakawa K. Fujimori K. Tanai H. Kimata M. Watanabe M. Hiraoka S. Chiba Y. Ishida S. Ono Y. Takiguchi S. Watanabe S. Yosida M. Hotuta T. Kusano J. Kanehori K. Takahashi-Fujii A. Hara H. Tanase T. -O. Nomura Y. Togiya S. Komai F. Hara R. Takeuchi K. Arita M. Imose N. Musashino K. Yuuki H. Oshima A. Sasaki N. Aotsuka S. Yoshikawa Y. Matsunawa H. Ichihara T. Shiohata N. Sano S. Moriya S. Momiyama H. Satoh N. Takami S. Terashima Y. Suzuki O. Nakagawa S. Senoh A. Mizoguchi H. Goto Y. Shimizu F. Wakebe H. Hishigaki H. Watanabe T. Sugiyama A. Takemoto M. Kawakami B. Yamazaki M. Watanabe K. Kumagai A. Itakura S. Fukuzumi Y. Fujimori Y. Komiyama M. Tashiro H. Tanigami A. Fujiwara T. Ono T. Yamada K. Fujii Y. Ozaki K. Hirao M. Ohmori Y. Kawabata A. Hikiji T. Kobatake N. Inagaki H. Ikema Y. Okamoto S. Okitani R. Kawakami T. Noguchi S. Itoh T. Shigeta K. Senba T. Matsumura K. Nakajima Y. Mizuno T. Morinaga M. Sasaki M. Togashi T. Oyama M. Hata H. Watanabe M. Komatsu T. Mizushima-Sugano J. Satoh T. Shirai Y. Takahashi Y. Nakagawa K. Okumura K. Nagase T. Nomura N. Kikuchi H. Masuho Y. Yamashita R. Nakai K. Yada T. Nakamura Y. Ohara O. Isogai T. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Thymus. [8] Mural R. J. Istrail S. Sutton G. G. Florea L. Halpern A. L. Mobarry C. M. Lippert R. Walenz B. Shatkay H. Dew I. Miller J. R. Flanigan M. J. Edwards N. J. Bolanos R. Fasulo D. Halldorsson B. V. Hannenhalli S. Turner R. Yooseph S. Lu F. Nusskern D. R. Shue B. C. Zheng X. H. Zhong F. Delcher A. L. Huson D. H. Kravitz S. A. Mouchard L. Reinert K. Remington K. A. Clark A. G. Waterman M. S. Eichler E. E. Adams M. D. Hunkapiller M. W. Myers E. W. Venter J. C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [9] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Blood. [10] \" PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. \" Ahn J. -Y. Rong R. Kroll T. G. Van Meir E. G. Snyder S. H. Ye K. J. Biol. Chem. 279:16441-16451(2004) [PubMed: 14761976] [Abstract]Cited for: TISSUE SPECIFICITY SUBCELLULAR LOCATION INTERACTION WITH AKT1 FUNCTION.
Amount: 0.1 mg
Available: In stock
Listprice: €274.04
Discount: -10.0%
Price: €246.64
You save: €27.40
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