Antibodies

MOUSE ANTI HUMAN CD92

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against Human
Applications IP
Amount 0.1 mg
Host Mouse
ArtNr 20-783-314628
Available
Genway ID:
GWB-8E2EC9
Specificity:
CD92
Isotype:
IgG2b
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgG concentration 1. 0mg/ml
Immunogen:
MV4-11 acute monocyte leukaemia cells.
Specificity:
Is specific for the C-terminal variant of human CD92 (isoform 3) also known as CTL1 a 70kDa multi-pass membrane protein expressed by monocytes neutrophils certain myeloid and T cell lines and weakly by endothelial cells fibroblasts and epithelial cells. CD92 is a member of the choline transporter-like protein family so called due to their involvement in the efficient supply/transport of the natural amine choline a vital cell nutrient required for the synthesis of cell membrane phospholipid components and the neurotransmitter acetylcholine. Clone VIM-15b is reported to augment the LPS-induced production of IL-10 by monocyte-derived dendritic cells (Mo-DCs) and the reduced expression of CD92 by Mo-DCs treated with ionomycin or calcium ionophore can be reinduced in the presence of IL-10(1). AbD Recommended Negative Controls: MOUSE IgG2b NEGATIVE CONTROLRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGRabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgGGoat Anti Mouse IgG IgA IgMRabbit Anti Mouse IgGHuCAL Anti Mouse IgG2bGoat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)
Function:
Choline transporter. May be involved in membrane synthesis and myelin production. Ref. 7Subcellular locationCell membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane proteinRef. 7. Tissue specificityExpressed in various cells of the hematopoietic system. Ref. 2Sequence similaritiesBelongs to the CTL (choline transporter-like) family. 1. Takaoda A et al (2007) DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448:501-5. 2. Schwartz T et al. (2001) Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins. Nat. Struct. Biol. 8:761-5 [1] \" Complex regulation of the human gene for the Z-DNA binding protein DLM-1. \" Rothenburg S. Schwartz T. Koch-Nolte F. Haag F. Nucleic Acids Res. 30:993-1000(2002) [PubMed: 11842111] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] ALTERNATIVE SPLICING VARIANT LYS-88. Tissue: Spleen. [2] \" The DNA sequence and comparative analysis of human chromosome 20. \" Deloukas P. Matthews L. H. Ashurst J. L. Burton J. Gilbert J. G. R. Jones M. Stavrides G. Almeida J. P. Babbage A. K. Bagguley C. L. Bailey J. Barlow K. F. Bates K. N. Beard L. M. Beare D. M. Beasley O. P. Bird C. P. Blakey S. E. Bridgeman A. M. Brown A. J. Buck D. Burrill W. D. Butler A. P. Carder C. Carter N. P. Chapman J. C. Clamp M. Clark G. Clark L. N. Clark S. Y. Clee C. M. Clegg S. Cobley V. E. Collier R. E. Connor R. E. Corby N. R. Coulson A. Coville G. J. Deadman R. Dhami P. D. Dunn M. Ellington A. G. Frankland J. A. Fraser A. French L. Garner P. Grafham D. V. Griffiths C. Griffiths M. N. D. Gwilliam R. Hall R. E. Hammond S. Harley J. L. Heath P. D. Ho S. Holden J. L. Howden P. J. Huckle E. Hunt A. R. Hunt S. E. Jekosch K. Johnson C. M. Johnson D. Kay M. P. Kimberley A. M. King A. Knights A. Laird G. K. Lawlor S. Lehvaeslaiho M. H. Leversha M. A. Lloyd C. Lloyd D. M. Lovell J. D. Marsh V. L. Martin S. L. McConnachie L. J. McLay K. McMurray A. A. Milne S. A. Mistry D. Moore M. J. F. Mullikin J. C. Nickerson T. Oliver K. Parker A. Patel R. Pearce T. A. V. Peck A. I. Phillimore B. J. C. T. Prathalingam S. R. Plumb R. W. Ramsay H. Rice C. M. Ross M. T. Scott C. E. Sehra H. K. Shownkeen R. Sims S. Skuce C. D. Smith M. L. Soderlund C. Steward C. A. Sulston J. E. Swann R. M. Sycamore N. Taylor R. Tee L. Thomas D. W. Thorpe A. Tracey A. Tromans A. C. Vaudin M. Wall M. Wallis J. M. Whitehead S. L. Whittaker P. Willey D. L. Williams L. Williams S. A. Wilming L. Wray P. W. Hubbard T. Durbin R. M. Bentley D. R. Beck S. Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [3] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Blood.
Amount: 0.1 mg
Available: In stock
Listprice: €326.19
Price: €326.19
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