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MOUSE ANTI HUMAN CD273

MOUSE ANTI HUMAN CD273

Manufacturer	GENWAY
Category	Oncology Antibodies Primary Antibodies By Organ Lung Cancer
Type	Antibody
Specific against	Human
Amount	0.1 mg
Host	Mouse
Item no.	20-783-314661
eClass 6.1	32160702
eClass 9.0	32160702
Available
Genway ID:	GWB-112DAB
Specificity:	CD273
Isotype:	IgG1
Preparation:	Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:	Phosphate buffered saline pH7. 4
Preservative Stabilisers:		0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgG concentration 1. 0mg/ml
Immunogen:	Human B7-DC transfected L cells.
Specificity:	Detects human CD273 also known as B7-DC and Programmed Death Ligand 2 (PD-L2). CD273 is a 42kD member of the immunoglobulin receptor superfamily and is a ligand for CD279 (PD-1). CD273 is primarily expressed on dendritic cells and its expression can be induced on inflammatory macrophages when activated by interleukin 4 or Th2 cells. CD273 functions to inhibit T-cell proliferation by blocking cell cycle progression and cytokine production and is particularly important in the maintenance of self tolerance. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROLRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgG1Goat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)
Function:	Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production By similarity. Subunit structureInteracts with PDCD1 By similarity. Subcellular locationIsoform 3: Secreted Probable Ref. 3. Isoform 2: Endomembrane system; Single-pass type I membrane proteinRef. 3. Isoform 1: Cell membrane; Single-pass type I membrane proteinRef. 3. Tissue specificityHighly expressed in heart placenta pancreas lung and liver and weakly expressed in spleen lymph nodes and thymus. Ref. 2Induction: Up-regulated by IFNG stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4. Ref. 2Ref. 1Sequence similaritiesBelongs to the immunoglobulin superfamily. BTN/MOG family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

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Amount: 0.1 mg

available

Delivery expected until 5/30/2024