MOUSE ANTI HUMAN CD273

Manufacturer GENWAY
Category
Type Antibody
Specific against Human
Amount 0.1 mg
Host Mouse
ArtNr 20-783-314661
Available
Genway ID:
GWB-112DAB
Specificity:
CD273
Isotype:
IgG1
Preparation:
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgG concentration 1. 0mg/ml
Immunogen:
Human B7-DC transfected L cells.
Specificity:
Detects human CD273 also known as B7-DC and Programmed Death Ligand 2 (PD-L2). CD273 is a 42kD member of the immunoglobulin receptor superfamily and is a ligand for CD279 (PD-1). CD273 is primarily expressed on dendritic cells and its expression can be induced on inflammatory macrophages when activated by interleukin 4 or Th2 cells. CD273 functions to inhibit T-cell proliferation by blocking cell cycle progression and cytokine production and is particularly important in the maintenance of self tolerance. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROLRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgG1Goat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)
Function:
Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production By similarity. Subunit structureInteracts with PDCD1 By similarity. Subcellular locationIsoform 3: Secreted Probable Ref. 3. Isoform 2: Endomembrane system; Single-pass type I membrane proteinRef. 3. Isoform 1: Cell membrane; Single-pass type I membrane proteinRef. 3. Tissue specificityHighly expressed in heart placenta pancreas lung and liver and weakly expressed in spleen lymph nodes and thymus. Ref. 2Induction: Up-regulated by IFNG stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL4. Ref. 2Ref. 1Sequence similaritiesBelongs to the immunoglobulin superfamily. BTN/MOG family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Amount: 0.1 mg
Available: In stock
Listprice: €326.19
Discount: -10.0%
Price: €293.57
You save: €32.62
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