Antibodies

MOUSE ANTI HUMAN CD56

Manufacturer GENWAY
Category Products / Antibody
Type Antibody
Specific against Human
Amount 0.1 mg
Host Mouse
ArtNr 20-783-314689
Available
Genway ID:
GWB-49B290
Specificity:
CD56
Isotype:
IgG1
Preparation:
Purified IgG prepared by affinity chromatography on Protein G
Buffer Solution:
Phosphate buffered saline pH7. 4
Preservative Stabilisers:
0. 09% Sodium Azide (NaN3)Approx. Protein Concentrations: IgG concentration 1. 0mg/ml
Immunogen:
Small cell lung carcinoma
Specificity:
Recognises human neural cell adhesion molecule (NCAM) otherwise known as CD56. The CD56 molecule is a cell surface glycoprotein which is expressed on neuroendocrine cells natural killer cells and a subset of T cells in the peripheral blood. Three main isoforms of CD56 exist. Neurons express the largest 180kD form while haemopoietic cells express the 140kD isoform. Antibodies produced by clone 123C3 recognise the 140 and 180kD isoforms of the CD56 protein. In neuronal tissues CD56 mediates homophilic and heterophilic adhesion and is implicated in neural development. Studies suggest that CD56 is also expressed on thyroid follicular epithelium and may play a role in autoimmune disease of the thyroid. CD56 is expressed in a range of tumours including tumours of the lung neural derived malignancies and natural killer cell lymphomas. Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROLRecommended Secondary Antibodies: Rabbit Anti Mouse IgGGoat Anti Mouse IgGGoat Anti Mouse IgG (H/L)Goat Anti Mouse IgG IgA IgMHuCAL Anti Mouse IgG1Goat Anti Mouse IgG (Fc)Sheep Anti Mouse IgG (H/L)
Function:
This protein is a cell adhesion molecule involved in neuron-neuron adhesion neurite fasciculation outgrowth of neurites etc. Subcellular locationIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Lipid-anchor & rsaquo; GPI-anchor. Isoform 4: Cell membrane; Lipid-anchor & rsaquo; GPI-anchor Potential. Isoform 5: Secreted. Isoform 6: Secreted Potential. Sequence similaritiesContains 2 fibronectin type-III domains. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. Sequence cautionThe sequence BAD92680. 1 differs from that shown. Reason: Erroneous initiation. [1] \" The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. \" Mitsui K. Tokuzawa Y. Itoh H. Segawa K. Murakami M. Takahashi K. Maruyama M. Maeda M. Yamanaka S. Cell 113:631-642(2003) [PubMed: 12787504] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) VARIANT ASN-82 TISSUE SPECIFICITY. Tissue: Embryonic stem cell. [2] \" Human STELLAR NANOG and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13 a hotspot for teratocarcinoma. \" Clark A. T. Rodriguez R. T. Bodnar M. S. Abeyta M. J. Cedars M. I. Turek P. J. Firpo M. T. Reijo Pera R. A. Stem Cells 22:169-179(2004) [PubMed: 14990856] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) TISSUE SPECIFICITY. Tissue: Embryonic stem cell. [3] \" Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog. \" Kim J. S. Kim J. Kim B. S. Chung H. Y. Lee Y. Y. Park C. -S. Lee Y. S. Lee Y. H. Chung I. Y. Exp. Mol. Med. 37:601-607(2005) [PubMed: 16391521] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2) FUNCTION DNA-BINDING TISSUE SPECIFICITY DEVELOPMENTAL STAGE. Tissue: Embryonic stem cell. [4] \" Complete sequencing and characterization of 21 243 full-length human cDNAs. \" Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. Kimura K. Makita H. Sekine M. Obayashi M. Nishi T. Shibahara T. Tanaka T. Ishii S. Yamamoto J. Saito K. Kawai Y. Isono Y. Nakamura Y. Nagahari K. Murakami K. Yasuda T. Iwayanagi T. Wagatsuma M. Shiratori A. Sudo H. Hosoiri T. Kaku Y. Kodaira H. Kondo H. Sugawara M. Takahashi M. Kanda K. Yokoi T. Furuya T. Kikkawa E. Omura Y. Abe K. Kamihara K. Katsuta N. Sato K. Tanikawa M. Yamazaki M. Ninomiya K. Ishibashi T. Yamashita H. Murakawa K. Fujimori K. Tanai H. Kimata M. Watanabe M. Hiraoka S. Chiba Y. Ishida S. Ono Y. Takiguchi S. Watanabe S. Yosida M. Hotuta T. Kusano J. Kanehori K. Takahashi-Fujii A. Hara H. Tanase T. -O. Nomura Y. Togiya S. Komai F. Hara R. Takeuchi K. Arita M. Imose N. Musashino K. Yuuki H. Oshima A. Sasaki N. Aotsuka S. Yoshikawa Y. Matsunawa H. Ichihara T. Shiohata N. Sano S. Moriya S. Momiyama H. Satoh N. Takami S. Terashima Y. Suzuki O. Nakagawa S. Senoh A. Mizoguchi H. Goto Y. Shimizu F. Wakebe H. Hishigaki H. Watanabe T. Sugiyama A. Takemoto M. Kawakami B. Yamazaki M. Watanabe K. Kumagai A. Itakura S. Fukuzumi Y. Fujimori Y. Komiyama M. Tashiro H. Tanigami A. Fujiwara T. Ono T. Yamada K. Fujii Y. Ozaki K. Hirao M. Ohmori Y. Kawabata A. Hikiji T. Kobatake N. Inagaki H. Ikema Y. Okamoto S. Okitani R. Kawakami T. Noguchi S. Itoh T. Shigeta K. Senba T. Matsumura K. Nakajima Y. Mizuno T. Morinaga M. Sasaki M. Togashi T. Oyama M. Hata H. Watanabe M. Komatsu T. Mizushima-Sugano J. Satoh T. Shirai Y. Takahashi Y. Nakagawa K. Okumura K. Nagase T. Nomura N. Kikuchi H. Masuho Y. Yamashita R. Nakai K. Yada T. Nakamura Y. Ohara O. Isogai T. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) VARIANT ASN-82. Tissue: Teratocarcinoma. [5] \" Functional expression cloning of Nanog a pluripotency sustaining factor in embryonic stem cells. \" Chambers I. Colby D. Robertson M. Nichols J. Lee S. Tweedie S. Smith A. Cell 113:643-655(2003) [PubMed: 12787505] [Abstract]Cited for: TISSUE SPECIFICITY. [6] \" Identification cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. \" Hart A. H. Hartley L. Ibrahim M. Robb L. Dev. Dyn. 230:187-198(2004) [PubMed: 15108323] [Abstract]Cited for: DEVELOPMENTAL STAGE. [7] \" Identification of a putative transactivation domain in human Nanog. \" Oh J. -H. Do H. -J. Yang H. -M. Moon S. -Y. Cha K. -Y. Chung H. -M. Kim J. -H. Exp. Mol. Med. 37:250-254(2005) [PubMed: 16000880] [Abstract]Cited for: FUNCTION. [8] \" Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes testicular carcinoma in situ and germ cell tumours. \" Hoei-Hansen C. E. Almstrup K. Nielsen J. E. Brask Sonne S. Graem N. Skakkebaek N. E. Leffers H. Rajpert-De Meyts E. Histopathology 47:48-56(2005) [PubMed: 15982323] [Abstract]Cited for: DEVELOPMENTAL STAGE TISSUE SPECIFICITY. [9] \" Pluripotential competence of cells associated with Nanog activity. \" Hatano S. Y. Tada M. Kimura H. Yamaguchi S. Kono T. Nakano T. Suemori H. Nakatsuji N. Tada T. Mech. Dev. 122:67-79(2005) [PubMed: 15582778] [Abstract]Cited for: DEVELOPMENTAL STAGE. [10] \" Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. \" Hyslop L. A. Stojkovic M. Armstrong L. Walter T. Stojkovic P. Przyborski S. Herbert M. Murdoch A. Strachan T. Lako M. Stem Cells 23:1035-1043(2005) [PubMed: 15983365] [Abstract]Cited for: FUNCTION SUBCELLULAR LOCATION DEVELOPMENTAL STAGE.
Amount: 0.1 mg
Available: In stock
Listprice: €326.19
Price: €326.19
lieferbar

Get an offer

Technische Fragen zu diesem Produkt?


Salesmanager: Arne Pelz

Email: sales@hoelzel.de

Close