MOUSE ANTI HUMAN CD56

GWB-49B290

IgG1

Phosphate buffered saline pH7. 4

Small cell lung carcinoma

This protein is a cell adhesion molecule involved in neuron-neuron adhesion neurite fasciculation outgrowth of neurites etc. Subcellular locationIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Lipid-anchor & rsaquo; GPI-anchor. Isoform 4: Cell membrane; Lipid-anchor & rsaquo; GPI-anchor Potential. Isoform 5: Secreted. Isoform 6: Secreted Potential. Sequence similaritiesContains 2 fibronectin type-III domains. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. Sequence cautionThe sequence BAD92680. 1 differs from that shown. Reason: Erroneous initiation. [1] \" The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. \" Mitsui K. Tokuzawa Y. Itoh H. Segawa K. Murakami M. Takahashi K. Maruyama M. Maeda M. Yamanaka S. Cell 113:631-642(2003) [PubMed: 12787504] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) VARIANT ASN-82 TISSUE SPECIFICITY. Tissue: Embryonic stem cell. [2] \" Human STELLAR NANOG and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13 a hotspot for teratocarcinoma. \" Clark A. T. Rodriguez R. T. Bodnar M. S. Abeyta M. J. Cedars M. I. Turek P. J. Firpo M. T. Reijo Pera R. A. Stem Cells 22:169-179(2004) [PubMed: 14990856] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1) TISSUE SPECIFICITY. Tissue: Embryonic stem cell. [3] \" Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog. \" Kim J. S. Kim J. Kim B. S. Chung H. Y. Lee Y. Y. Park C. -S. Lee Y. S. Lee Y. H. Chung I. Y. Exp. Mol. Med. 37:601-607(2005) [PubMed: 16391521] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2) FUNCTION DNA-BINDING TISSUE SPECIFICITY DEVELOPMENTAL STAGE. Tissue: Embryonic stem cell. [4] \" Complete sequencing and characterization of 21 243 full-length human cDNAs. \" Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. Kimura K. Makita H. Sekine M. Obayashi M. Nishi T. Shibahara T. Tanaka T. Ishii S. Yamamoto J. Saito K. Kawai Y. Isono Y. Nakamura Y. Nagahari K. Murakami K. Yasuda T. Iwayanagi T. Wagatsuma M. Shiratori A. Sudo H. Hosoiri T. Kaku Y. Kodaira H. Kondo H. Sugawara M. Takahashi M. Kanda K. Yokoi T. Furuya T. Kikkawa E. Omura Y. Abe K. Kamihara K. Katsuta N. Sato K. Tanikawa M. Yamazaki M. Ninomiya K. Ishibashi T. Yamashita H. Murakawa K. Fujimori K. Tanai H. Kimata M. Watanabe M. Hiraoka S. Chiba Y. Ishida S. Ono Y. Takiguchi S. Watanabe S. Yosida M. Hotuta T. Kusano J. Kanehori K. Takahashi-Fujii A. Hara H. Tanase T. -O. Nomura Y. Togiya S. Komai F. Hara R. Takeuchi K. Arita M. Imose N. Musashino K. Yuuki H. Oshima A. Sasaki N. Aotsuka S. Yoshikawa Y. Matsunawa H. Ichihara T. Shiohata N. Sano S. Moriya S. Momiyama H. Satoh N. Takami S. Terashima Y. Suzuki O. Nakagawa S. Senoh A. Mizoguchi H. Goto Y. Shimizu F. Wakebe H. Hishigaki H. Watanabe T. Sugiyama A. Takemoto M. Kawakami B. Yamazaki M. Watanabe K. Kumagai A. Itakura S. Fukuzumi Y. Fujimori Y. Komiyama M. Tashiro H. Tanigami A. Fujiwara T. Ono T. Yamada K. Fujii Y. Ozaki K. Hirao M. Ohmori Y. Kawabata A. Hikiji T. Kobatake N. Inagaki H. Ikema Y. Okamoto S. Okitani R. Kawakami T. Noguchi S. Itoh T. Shigeta K. Senba T. Matsumura K. Nakajima Y. Mizuno T. Morinaga M. Sasaki M. Togashi T. Oyama M. Hata H. Watanabe M. Komatsu T. Mizushima-Sugano J. Satoh T. Shirai Y. Takahashi Y. Nakagawa K. Okumura K. Nagase T. Nomura N. Kikuchi H. Masuho Y. Yamashita R. Nakai K. Yada T. Nakamura Y. Ohara O. Isogai T. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) VARIANT ASN-82. Tissue: Teratocarcinoma. [5] \" Functional expression cloning of Nanog a pluripotency sustaining factor in embryonic stem cells. \" Chambers I. Colby D. Robertson M. Nichols J. Lee S. Tweedie S. Smith A. Cell 113:643-655(2003) [PubMed: 12787505] [Abstract]Cited for: TISSUE SPECIFICITY. [6] \" Identification cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. \" Hart A. H. Hartley L. Ibrahim M. Robb L. Dev. Dyn. 230:187-198(2004) [PubMed: 15108323] [Abstract]Cited for: DEVELOPMENTAL STAGE. [7] \" Identification of a putative transactivation domain in human Nanog. \" Oh J. -H. Do H. -J. Yang H. -M. Moon S. -Y. Cha K. -Y. Chung H. -M. Kim J. -H. Exp. Mol. Med. 37:250-254(2005) [PubMed: 16000880] [Abstract]Cited for: FUNCTION. [8] \" Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes testicular carcinoma in situ and germ cell tumours. \" Hoei-Hansen C. E. Almstrup K. Nielsen J. E. Brask Sonne S. Graem N. Skakkebaek N. E. Leffers H. Rajpert-De Meyts E. Histopathology 47:48-56(2005) [PubMed: 15982323] [Abstract]Cited for: DEVELOPMENTAL STAGE TISSUE SPECIFICITY. [9] \" Pluripotential competence of cells associated with Nanog activity. \" Hatano S. Y. Tada M. Kimura H. Yamaguchi S. Kono T. Nakano T. Suemori H. Nakatsuji N. Tada T. Mech. Dev. 122:67-79(2005) [PubMed: 15582778] [Abstract]Cited for: DEVELOPMENTAL STAGE. [10] \" Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. \" Hyslop L. A. Stojkovic M. Armstrong L. Walter T. Stojkovic P. Przyborski S. Herbert M. Murdoch A. Strachan T. Lako M. Stem Cells 23:1035-1043(2005) [PubMed: 15983365] [Abstract]Cited for: FUNCTION SUBCELLULAR LOCATION DEVELOPMENTAL STAGE.