MOUSE ANTI HUMAN CD10:RPE

CD10

Purified IgG prepared by affinity chromatography on Protein G

Recognises the human CD10 cell surface antigen a 100kD glycoprotein expressed by acute lymphoblastic leukaemia cells and by peripheral blood granulocytes. CD10 is also known as the Common Acute Lymphoblastic Leukaemia Antigen (CALLA). Recommended Negative Controls: MOUSE IgG1 NEGATIVE CONTROL:RPE

Important cell surface marker in the diagnostic of human acute lymphocytic leukemia. Sequence similaritiesBelongs to the peptidase M13 family. Biophysicochemical properties Kinetic parameters:KM=55. 1 & micro; M for angiotensin-1 Ref. 11KM=179 & micro; M for angiotensin-2KM=111. 4 & micro; M for angiotensin 1-9Sequence cautionThe sequence CAA30157. 1 differs from that shown. Reason: Erroneous initiation. [1] \" Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. \" Mastroberardino L. Spindler B. Pfeiffer R. Skelly P. J. Loffing J. Shoemaker C. B. Verrey F. Nature 395:288-291(1998) [PubMed: 9751058] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] FUNCTION SUBUNIT VARIANT LYS-230. [2] \" Human LAT1 a subunit of system L amino acid transporter: molecular cloning and transport function. \" Prasad P. D. Wang H. Huang W. Kekuda R. Rajan D. P. Leibach F. H. Ganapathy V. Biochem. Biophys. Res. Commun. 255:283-288(1999) [PubMed: 10049700] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] FUNCTION SUBUNIT TISSUE SPECIFICITY. Tissue: Placenta. [3] \" Primary structure of the light chain of fusion regulatory protein-1/CD98/4F2 predicts a protein with multiple transmembrane domains that is almost identical to the amino acid transporter E16. \" Tsurudome M. Ito M. Takebayashi S. Okumura K. Nishio M. Kawano M. Kusagawa S. Komada H. Ito Y. J. Immunol. 162:2462-2466(1999) [PubMed: 10072483] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] PARTIAL PROTEIN SEQUENCE TISSUE SPECIFICITY. [4] \" Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. \" Yanagida O. Kanai Y. Chairoungdua A. Kim D. K. Segawa H. Nii T. Cha S. H. Matsuo H. Fukushima J. Fukasawa Y. Tani Y. Taketani Y. Uchino H. Kim J. Y. Inatomi J. Okayasu I. Miyamoto K. Takeda E. Goya T. Endou H. Biochim. Biophys. Acta 1514:291-302(2001) [PubMed: 11557028] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] FUNCTION SUBUNIT TISSUE SPECIFICITY. Tissue: Ovary. [5] \" Human 4F2 light chain: amino acid transporter. \" Minato N. Iwai K. Takizawa C. Nakamura E. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. [6] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver. [7] \" A novel transiently expressed integral membrane protein linked to cell activation. Molecular cloning via the rapid degradation signal AUUUA. \" Gaugitsch H. W. Prieschl E. E. Kalthoff F. Huber N. E. Baumruker T. J. Biol. Chem. 267:11267-11273(1992) [PubMed: 1597461] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-507 TISSUE SPECIFICITY INDUCTION. Tissue: Peripheral blood lymphocyte. [8] \" Identification of a membrane protein LAT-2 that co-expresses with 4F2 heavy chain an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. \" Pineda M. Fernandez E. Torrents D. Estevez R. Lopez C. Camps M. Lloberas J. Zorzano A. Palacin M. J. Biol. Chem. 274:19738-19744(1999) [PubMed: 10391915] [Abstract]Cited for: FUNCTION INHIBITION. [9] \" LAT2 a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. \" Rossier G. Meier C. Bauch C. Summa V. Sordat B. Verrey F. Kuehn L. C. J. Biol. Chem. 274:34948-34954(1999) [PubMed: 10574970] [Abstract]Cited for: FUNCTION BIOPHYSICOCHEMICAL PROPERTIES. [10] \" Association of 4F2hc with light chains LAT1 LAT2 or y+LAT2 requires different domains. \" Broeer A. Friedrich B. Wagner C. A. Fillon S. Ganapathy V. Lang F. Broeer S. Biochem. J. 355:725-731(2001) [PubMed: 11311135] [Abstract]Cited for: FUNCTION SUBUNIT SUBCELLULAR LOCATION.