MOUSE ANTI HUMAN CD55:RPE

CD55

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb the amplification convertases of the complement cascade. Ref. 14Subunit structureMonomer (major form) and non-disulfide-linked covalent homodimer (minor form). Binds to coxsackievirus A21 coxsackieviruses B1 B3 and B5 human enterovirus 70 human echoviruses 6 7 11 12 20 and 21 capsid proteins and acts as a receptor for these viruses. Ref. 13Ref. 15Ref. 16Ref. 17Ref. 18Ref. 22Subcellular locationIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Lipid-anchor & rsaquo; GPI-anchor. Tissue specificityExpressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments and variants of the molecule are present in body fluids and in extracellular matrix.

Responsible for the Cromer blood group system. It consists of at least 8 high-incidence (Cr(a) Tc(a) Dr(a) Es(a) WES(b) UMC IFC and GUTI) and three low-incidence (Tc(b) Tc(c) and WES(a)) antigens that reside on DAF. In the Cromer phenotypes Dr(a-) and Inab there is reduced or absent expression of DAF respectively. In the case of the Dr(a-) phenotype a single nucleotide substitution within exon 5 accounts for two changes: a simple amino acid substitution Leu-199 that is the basis of the antigenic variation and an alternative splicing event that underlies the decreased expression of DAF in this phenotype. The Inab phenotype is a very rare one in which the red blood cells lack all Cromer system antigens. The red blood cells of individuals with Inab phenotype have a deficiency of DAF but these individuals are not known to have any associated hematologic or other abnormalities. Sequence similaritiesBelongs to the receptors of complement activation (RCA) family. Contains 4 Sushi (CCP/SCR) domains. [1] \" The human neurokinin A (substance K) receptor. Molecular cloning of the gene chromosome localization and isolation of cDNA from tracheal and gastric tissues. \" Gerard N. P. Eddy R. L. Jr. Shows T. B. Gerard C. J. Biol. Chem. 265:20455-20462(1990) [PubMed: 2173708] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] VARIANT LYS-245. Tissue: Stomach and Trachea. [2] ErratumGerard N. P. Eddy R. L. Jr. Shows T. B. Gerard C. J. Biol. Chem. 266:1354-1354(1991) [PubMed: 1845990] [Abstract] [3] \" Molecular cloning of the human neurokinin-2 receptor cDNA by polymerase chain reaction and isolation of the gene. \" Gerard N. P. Gerard C. Ann. N. Y. Acad. Sci. 632:389-390(1991) [PubMed: 1659296] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA]. [4] \" Cloning expression of the human substance K receptor and analysis of its role in mitogenesis. \" Cyr C. South V. Saltzman A. Felder S. Ricca G. A. Jaye M. Huebner K. Kagan J. Croce C. M. Schlessinger J. Ann. N. Y. Acad. Sci. 632:426-427(1991) [PubMed: 1659297] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] FUNCTION VARIANTS THR-23 AND LYS-245. Tissue: Jejunum. [5] \" Isolation and characterisation of the human lung NK-2 receptor gene using rapid amplification of cDNA ends. \" Graham A. Hopkins B. Powell S. J. Danks P. Briggs I. Biochem. Biophys. Res. Commun. 177:8-16(1991) [PubMed: 1710456] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANTS THR-23 AND LYS-245. Tissue: Lung. [6] \" Cloning and expression of the human substance K receptor and analysis of its role in mitogenesis. \" Kris R. M. South V. Saltzman A. Felder S. Ricca G. A. Jaye M. Huebner K. Kagan J. Croce C. M. Schlessinger J. Cell Growth Differ. 2:15-22(1991) [PubMed: 1848773] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANT HIS-375. [7] \" Genome-wide discovery and analysis of human seven transmembrane helix receptor genes. \" Suwa M. Sato T. Okouchi I. Arita M. Futami K. Matsumoto S. Tsutsumi S. Aburatani H. Asai K. Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [8] \" Complete sequencing and characterization of 21 243 full-length human cDNAs. \" Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. Kimura K. Makita H. Sekine M. Obayashi M. Nishi T. Shibahara T. Tanaka T. Ishii S. Yamamoto J. Saito K. Kawai Y. Isono Y. Nakamura Y. Nagahari K. Murakami K. Yasuda T. Iwayanagi T. Wagatsuma M. Shiratori A. Sudo H. Hosoiri T. Kaku Y. Kodaira H. Kondo H. Sugawara M. Takahashi M. Kanda K. Yokoi T. Furuya T. Kikkawa E. Omura Y. Abe K. Kamihara K. Katsuta N. Sato K. Tanikawa M. Yamazaki M. Ninomiya K. Ishibashi T. Yamashita H. Murakawa K. Fujimori K. Tanai H. Kimata M. Watanabe M. Hiraoka S. Chiba Y. Ishida S. Ono Y. Takiguchi S. Watanabe S. Yosida M. Hotuta T. Kusano J. Kanehori K. Takahashi-Fujii A. Hara H. Tanase T. -O. Nomura Y. Togiya S. Komai F. Hara R. Takeuchi K. Arita M. Imose N. Musashino K. Yuuki H. Oshima A. Sasaki N. Aotsuka S. Yoshikawa Y. Matsunawa H. Ichihara T. Shiohata N. Sano S. Moriya S. Momiyama H. Satoh N. Takami S. Terashima Y. Suzuki O. Nakagawa S. Senoh A. Mizoguchi H. Goto Y. Shimizu F. Wakebe H. Hishigaki H. Watanabe T. Sugiyama A. Takemoto M. Kawakami B. Yamazaki M. Watanabe K. Kumagai A. Itakura S. Fukuzumi Y. Fujimori Y. Komiyama M. Tashiro H. Tanigami A. Fujiwara T. Ono T. Yamada K. Fujii Y. Ozaki K. Hirao M. Ohmori Y. Kawabata A. Hikiji T. Kobatake N. Inagaki H. Ikema Y. Okamoto S. Okitani R. Kawakami T. Noguchi S. Itoh T. Shigeta K. Senba T. Matsumura K. Nakajima Y. Mizuno T. Morinaga M. Sasaki M. Togashi T. Oyama M. Hata H. Watanabe M. Komatsu T. Mizushima-Sugano J. Satoh T. Shirai Y. Takahashi Y. Nakagawa K. Okumura K. Nagase T. Nomura N. Kikuchi H. Masuho Y. Yamashita R. Nakai K. Yada T. Nakamura Y. Ohara O. Isogai T. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] VARIANT LYS-245. Tissue: Small intestine. [9] \" cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www. cdna. org). \" Kopatz S. A. Aronstam R. S. Sharma S. V. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] VARIANT LYS-245. Tissue: Stomach. [10] Mural R. J. Istrail S. Sutton G. G. Florea L. Halpern A. L. Mobarry C. M. Lippert R. Walenz B. Shatkay H. Dew I. Miller J. R. Flanigan M. J. Edwards N. J. Bolanos R. Fasulo D. Halldorsson B. V. Hannenhalli S. Turner R. Yooseph S. Lu F. Nusskern D. R. Shue B. C. Zheng X. H. Zhong F. Delcher A. L. Huson D. H. Kravitz S. A. Mouchard L. Reinert K. Remington K. A. Clark A. G. Waterman M. S. Eichler E. E. Adams M. D. Hunkapiller M. W. Myers E. W. Venter J. C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] VARIANT LYS-245.