RABBIT ANTI HUMAN INSULIN-LIKE GROWTH FACTOR I:Biotin

IGF-I

Phosphate buffered saline pH7. 2

Recombinant human IGF-I

The insulin-like growth factors isolated from plasma are structurally and functionally related to insulin but have a much higher growth-promoting activity. Subcellular locationSecreted. Involvement in diseaseDefects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation sensorineural deafness and mental retardation. Sequence similaritiesBelongs to the insulin family. Sequence cautionThe sequence CAA27250. 1 differs from that shown. Reason: Erroneous gene model prediction. 1. Drbal K. et al. (2001) A proteolytically truncated form of free CD18 the common chain of leukocyte integrins as a novel marker of activated myeloid cells. Blood. 98: 1561 - 1566. [1] \" Cloning of the beta subunit of the leukocyte adhesion proteins: homology to an extracellular matrix receptor defines a novel supergene family. \" Kishimoto T. K. O\' Connor K. Lee A. Roberts T. M. Springer T. A. Cell 48:681-690(1987) [PubMed: 3028646] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] VARIANT HIS-354. [2] \" The gene organisation of the human beta 2 integrin subunit (CD18). \" Weitzman J. B. Wells C. E. Wright A. H. Clark P. A. Law S. K. A. FEBS Lett. 294:97-103(1991) [PubMed: 1683838] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] VARIANT HIS-354. [3] \" Complete sequencing and characterization of 21 243 full-length human cDNAs. \" Ota T. Suzuki Y. Nishikawa T. Otsuki T. Sugiyama T. Irie R. Wakamatsu A. Hayashi K. Sato H. Nagai K. Kimura K. Makita H. Sekine M. Obayashi M. Nishi T. Shibahara T. Tanaka T. Ishii S. Yamamoto J. Saito K. Kawai Y. Isono Y. Nakamura Y. Nagahari K. Murakami K. Yasuda T. Iwayanagi T. Wagatsuma M. Shiratori A. Sudo H. Hosoiri T. Kaku Y. Kodaira H. Kondo H. Sugawara M. Takahashi M. Kanda K. Yokoi T. Furuya T. Kikkawa E. Omura Y. Abe K. Kamihara K. Katsuta N. Sato K. Tanikawa M. Yamazaki M. Ninomiya K. Ishibashi T. Yamashita H. Murakawa K. Fujimori K. Tanai H. Kimata M. Watanabe M. Hiraoka S. Chiba Y. Ishida S. Ono Y. Takiguchi S. Watanabe S. Yosida M. Hotuta T. Kusano J. Kanehori K. Takahashi-Fujii A. Hara H. Tanase T. -O. Nomura Y. Togiya S. Komai F. Hara R. Takeuchi K. Arita M. Imose N. Musashino K. Yuuki H. Oshima A. Sasaki N. Aotsuka S. Yoshikawa Y. Matsunawa H. Ichihara T. Shiohata N. Sano S. Moriya S. Momiyama H. Satoh N. Takami S. Terashima Y. Suzuki O. Nakagawa S. Senoh A. Mizoguchi H. Goto Y. Shimizu F. Wakebe H. Hishigaki H. Watanabe T. Sugiyama A. Takemoto M. Kawakami B. Yamazaki M. Watanabe K. Kumagai A. Itakura S. Fukuzumi Y. Fujimori Y. Komiyama M. Tashiro H. Tanigami A. Fujiwara T. Ono T. Yamada K. Fujii Y. Ozaki K. Hirao M. Ohmori Y. Kawabata A. Hikiji T. Kobatake N. Inagaki H. Ikema Y. Okamoto S. Okitani R. Kawakami T. Noguchi S. Itoh T. Shigeta K. Senba T. Matsumura K. Nakajima Y. Mizuno T. Morinaga M. Sasaki M. Togashi T. Oyama M. Hata H. Watanabe M. Komatsu T. Mizushima-Sugano J. Satoh T. Shirai Y. Takahashi Y. Nakagawa K. Okumura K. Nagase T. Nomura N. Kikuchi H. Masuho Y. Yamashita R. Nakai K. Yada T. Nakamura Y. Ohara O. Isogai T. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] VARIANT HIS-354. Tissue: Synovial cell. [4] Suzuki Y. Sugano S. Totoki Y. Toyoda A. Takeda T. Sakaki Y. Tanaka A. Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] VARIANT HIS-354. Tissue: Adipose tissue. [5] \" The DNA sequence of human chromosome 21. \" Hattori M. Fujiyama A. Taylor T. D. Watanabe H. Yada T. Park H. -S. Toyoda A. Ishii K. Totoki Y. Choi D. -K. Groner Y. Soeda E. Ohki M. Takagi T. Sakaki Y. Taudien S. Blechschmidt K. Polley A. Menzel U. Delabar J. Kumpf K. Lehmann R. Patterson D. Reichwald K. Rump A. Schillhabel M. Schudy A. Zimmermann W. Rosenthal A. Kudoh J. Shibuya K. Kawasaki K. Asakawa S. Shintani A. Sasaki T. Nagamine K. Mitsuyama S. Antonarakis S. E. Minoshima S. Shimizu N. Nordsiek G. Hornischer K. Brandt P. Scharfe M. Schoen O. Desario A. Reichelt J. Kauer G. Bloecker H. Ramser J. Beck A. Klages S. Hennig S. Riesselmann L. Dagand E. Wehrmeyer S. Borzym K. Gardiner K. Nizetic D. Francis F. Lehrach H. Reinhardt R. Yaspo M. -L. Nature 405:311-319(2000) [PubMed: 10830953] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. [6] \" The status quality and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). \" The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] VARIANT HIS-354. Tissue: Muscle. [7] \" The primary structure of the beta-subunit of the cell surface adhesion glycoproteins LFA-1 CR3 and p150 95 and its relationship to the fibronectin receptor. \" Law S. K. A. Gagnon J. Hildreth J. E. Wells C. E. Willis A. C. Wong A. J. EMBO J. 6:915-919(1987) [PubMed: 2954816] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-769 PARTIAL PROTEIN SEQUENCE VARIANT HIS-354. Tissue: Spleen. [8] \" Familial genetic defect in a case of leukocyte adhesion deficiency. \" Ohashi Y. Yambe T. Tsuchiya S. Kikuchi H. Konno T. Hum. Mutat. 2:458-467(1993) [PubMed: 7509236] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 124-199 VARIANT LAD1 LEU-178. Tissue: Lymphoblast. [9] \" Genetic cause of leukocyte adhesion molecule deficiency. Abnormal splicing and a missense mutation in a conserved region of CD18 impair cell surface expression of beta 2 integrins. \" Nelson C. Rabb H. Arnaout M. A. J. Biol. Chem. 267:3351-3357(1992) [PubMed: 1346613] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 347-355 VARIANTS LAD1 SER-351 AND TRP-586 VARIANT HIS-354. [10] \" Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. \" Bianchi E. Denti S. Granata A. Bossi G. Geginat J. Villa A. Rogge L. Pardi R. Nature 404:617-621(2000) [PubMed: 10766246] [Abstract]Cited for: INTERACTION WITH COPS5.